Acupuncture suppresses intrastriatal hemorrhage-induced apoptotic neuronal cell death in rats

被引：25

作者：

Cho, NH

Lee, JD

Cheong, BS

Choi, DY

Chang, HK

Lee, TH

Shin, MC

Shin, MS

Lee, J

Kim, CJ

机构：

[1] Kyung Hee Univ, Coll Med, Dept Physiol, Seoul 130701, South Korea

[2] Kyung Hee Univ, Coll Oriental Med, Dept Acupuncture & Moxibust, Seoul, South Korea

[3] Johns Hopkins Univ, Sch Med, Dept Pediat Infect Dis, Baltimore, MD USA

来源：

NEUROSCIENCE LETTERS | 2004年 / 362卷 / 02期

关键词：

intrastriatal hemorrhage; acupuncture; Zusanli acupoint; apoptosis; caspase-3;

D O I：

10.1016/j.neulet.2004.03.027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intracerebral hemorrhage is one of the most devastating types of stroke. In the present study, the effect of acupuncture on intrastriatal hemorrhage-induced neuronal cell death in rats was investigated via Nissl staining, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay. and immunohistochemistry for caspase-3. The present results showed that lesion size and apoptotic neuronal cell death in the striatum were significantly increased following intrastriatal hemorrhage in rats and that acupunctural treatment at the Zusanli acupoint suppressed the hemorrhage-induced increase in lesion size and apoptotic neuronal cell death in the striatum. In the present study, it can be suggested that acupunctural treatment, especially at the Zusanli acupoint, may aid in the recovery following central nervous system sequellae following intracerebral hemorrhage. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：141 / 145

页数：5

共 28 条

[1] Expression of interleukin-1 beta converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery [J].