Adipose tissue mass can be regulated through the vasculature

被引：635

作者：

Rupnick, MA

Panigrahy, D

Zhang, CY

Dallabrida, SM

Lowell, BB

Langer, R

Folkman, MJ

机构：

[1] Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA 02115 USA

[2] Beth Israel Deaconess Med Ctr, Div Endocrinol, Boston, MA 02115 USA

[3] Childrens Hosp, Div Surg Res, Boston, MA 02115 USA

[4] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 16期

关键词：

D O I：

10.1073/pnas.162349799

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tumor growth is angiogenesis dependent. We hypothesized that nonneoplastic tissue growth also depends on neovascularization. We chose adipose tissue as an experimental system because of its remodeling capacity. Mice from different obesity models received anti-angiogenic agents. Treatment resulted in dose-dependent, reversible weight reduction and adipose tissue loss. Marked vascular remodeling was evident in adipose tissue sections, which revealed decreased endothelial proliferation and increased apoptosis in treated mice compared with controls. Continuous treatment maintained mice near normal body weights for age without adverse effects. Metabolic adaptations in food intake, metabolic rate, and energy substrate utilization were associated with anti-angiogenic weight loss. We conclude that adipose tissue mass is sensitive to angiogenesis inhibitors and can be regulated by its vasculature.

引用

页码：10730 / 10735

页数：6

共 47 条

[1] Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
Boehm, T
Folkman, J
Browder, T
OReilly, MS
[J]. NATURE, 1997, 390 (6658) : 404 - 407
[2] The OB protein (leptin) pathway - A link between adipose tissue mass and central neural networks
Campfield, LA
Smith, FJ
Burn, P
[J]. HORMONE AND METABOLIC RESEARCH, 1996, 28 (12) : 619 - 632
[3] CARR RH, 1977, P SOC EXP BIOL MED, V154, P116, DOI 10.3181/00379727-154-39616
[4] POTENT STIMULATION OF VASCULAR ENDOTHELIAL CELL-GROWTH BY DIFFERENTIATED 3T3 ADIPOCYTES
CASTELLOT, JJ
KARNOVSKY, MJ
SPIEGELMAN, BM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (10): : 6007 - 6011
[5] INDUCTION OF OBESITY IN OBESE-HYPERGLYCAEMIC MICE ON NORMAL FOOD INTAKE
CHLOUVERAKIS, C
[J]. EXPERIENTIA, 1970, 26 (11): : 1262 - +
[6] Leptin induces angiopoietin-2 expression in adipose tissues
Cohen, B
Barkan, D
Levy, Y
Goldberg, I
Fridman, E
Kopolovic, J
Rubinstein, M
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (11) : 7697 - 7700
[7] INFLUENCE OF GENETIC BACKGROUND ON EXPRESSION OF OBESE (OB) GENE IN MOUSE
COLEMAN, DL
HUMMEL, KP
[J]. DIABETOLOGIA, 1973, 9 (04) : 287 - 293
[8] A review of the microcirculation of adipose tissue: Anatomic, metabolic and angiogenic perspectives
Crandall, DL
Hausman, GJ
Kral, JG
[J]. MICROCIRCULATION-LONDON, 1997, 4 (02): : 211 - 232
[9] THALIDOMIDE IS AN INHIBITOR OF ANGIOGENESIS
DAMATO, RJ
LOUGHNAN, MS
FLYNN, E
FOLKMAN, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) : 4082 - 4085
[10] 1-BUTYRYL-GLYCEROL - A NOVEL ANGIOGENESIS FACTOR SECRETED BY DIFFERENTIATING ADIPOCYTES
DOBSON, DE
KAMBE, A
BLOCK, E
DION, T
LU, H
CASTELLOT, JJ
SPIEGELMAN, BM
[J]. CELL, 1990, 61 (02) : 223 - 230

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