Auto-regulated osmotic pump for insulin therapy by sensing glucose concentration without energy supply

被引：11

作者：

Nagakura, T ^{[1
]}

Ishihara, K ^{[1
]}

Furukawa, T ^{[1
]}

Masuda, K ^{[1
]}

Tsuda, T ^{[1
]}

机构：

[1] OSAKA UNIV,FAC ENGN,SUITA,OSAKA 565,JAPAN

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 1996年 / 34卷 / 1-3期

关键词：

osmotic pump; semipermeable membrane; insulin pump; blood sugar; diabetes mellitus; mechanochemical actuator;

D O I：

10.1016/S0925-4005(96)01954-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We designed an osmotic pump, using a semipermeable membrane which changes its volume according to the concentration of an outside solution. No energy supply or regulation system are required. This pump directly converts chemical potential to mechanical action without an intermediary like an electrical apparatus, called a mechanochemical actuator. This mechanism was applied to an insulin pump that works by changing the glucose concentration, We demonstrated that this pump may possibly be used in the treatment of diabetes mellitus patients.

引用

页码：229 / 233

页数：5