Novel radical reaction of phenylsulfonyl oxime ethers. A free radical acylation approach

Although acylation represents one of the most useful and thoroughly studied reactions in organic chemistry, a successful free radical mediated acylation is not presently available. free radical carbonylation has recently been reported. This reaction allows the introduction of carbonyl groups to organic halides. In order to examine the feasibility of radical mediated acylation reactions, we began our study with thiol esters as radical acceptors, we have discovered the first successful radical acylation approach which we believe has great synthetic potential because it succeeds in complex molecules, where more conventional synthetic methods would be inappropriate.