Autonomous modes of behavior in primordial germ cell migration

被引：79

作者：

Reichman-Fried, M ^{[1
]}

Minina, S ^{[1
]}

Raz, E ^{[1
]}

机构：

[1] Max Planck Inst Biophys Chem, Gern Cell Dev, D-37077 Gottingen, Germany

来源：

DEVELOPMENTAL CELL | 2004年 / 6卷 / 04期

关键词：

D O I：

10.1016/S1534-5807(04)00074-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Zebrafish primordial germ cells (PGCs) are guided toward their targets by the chemokine SDF-1a. PGCs were followed during three phases of their migration: when migrating as individual cells, while remaining in a clustered configuration, and when moving as a cell cluster within the embryo. We found that individually migrating PGCs alternate between migratory and pausing modes. Pausing intervals are characterized by loss of cell polarity and correlate with subsequent changes in the direction of migration. These properties constitute an intrinsic behavior of PGCs, enabling erasure of prior polarity and re-sampling of the environment. Following migration arrest at a site of high SDF-1a levels, PGCs resume migration as a cluster. The seemingly coordinated cluster migration is a result of single-cell movement in response to local variations in SDF-1a distribution. Together, these behavioral modes allow the cells to arrive at specific destinations with high fidelity and remain at their target site.

引用

页码：589 / 596

页数：8

共 35 条

[1] Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1) [J].

Ara, T ;

Nakamura, Y ;

Egawa, T ;

Sugiyama, T ;

Abe, K ;

Kishimoto, T ;

Matsui, Y ;

Nagasawa, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :5319-5323

[2]

BERG HC, 1972, NATURE, V239, P500, DOI 10.1038/239500a0

[3] Chemokine receptors in inflammation: an overview [J].

D'Ambrosio, D ;

Panina-Bordignon, P ;

Sinigaglia, F .

JOURNAL OF IMMUNOLOGICAL METHODS, 2003, 273 (1-2) :3-13

[4] Eukaryotic chemotaxis: Distinctions between directional sensing and polarization [J].

Devreotes, P ;

Janetopoulos, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (23) :20445-20448

[5] Molecular mechanisms of axon guidance [J].

Dickson, BJ .

SCIENCE, 2002, 298 (5600) :1959-1964

[6] Guidance of primordial germ cell migration by the chemokine SDF-1 [J].

Doitsidou, M ;

Reichman-Fried, M ;

Stebler, J ;

Köprunner, M ;

Dörries, J ;

Meyer, D ;

Esguerra, CV ;

Leung, T ;

Raz, E .

CELL, 2002, 111 (05) :647-659

[7] Zebrafish: a model system for the study of human disease [J].

Dooley, K ;

Zon, LI .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2000, 10 (03) :252-256

[8] Tumour-cell invasion and migration: Diversity and escape mechanisms [J].

Friedl, P ;

Wolf, K .

NATURE REVIEWS CANCER, 2003, 3 (05) :362-374

[9] Invasive cell migration is initiated by guided growth of long cellular extensions [J].

Fulga, TA ;

Rorth, P .

NATURE CELL BIOLOGY, 2002, 4 (09) :715-719

[10] The EGF-CFC protein one-eyed pinhead is essential for nodal signaling [J].

Gritsman, K ;

Zhang, JJ ;

Cheng, S ;

Heckscher, E ;

Talbot, WS ;

Schier, AF .

CELL, 1999, 97 (01) :121-132

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