Proton spectroscopy in asymptomatic HIV-infected adults: Initial results in a prospective cohort study

被引:34
作者
Jarvik, JG
Lenkinski, RE
Saykin, AJ
Jaans, A
Frank, I
机构
[1] HOSP UNIV PENN,DEPT INTERNAL MED,DIV INFECT DIS,PHILADELPHIA,PA 19104
[2] DARTMOUTH HITCHCOCK MED CTR,DEPT PSYCHIAT,HANOVER,NH
[3] CHILDRENS HOSP PHILADELPHIA,DEPT NEUROL,PHILADELPHIA,PA 19104
[4] HOSP UNIV PENN,DEPT RADIOL,PHILADELPHIA,PA 19104
来源
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY | 1996年 / 13卷 / 03期
关键词
HIV; magnetic resonance spectroscopy;
D O I
10.1097/00042560-199611010-00006
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The purpose of our study was to determine whether proton magnetic resonance spectroscopy (MRS) could detect early brain involvement by human immunodeficiency virus (HIV). We recruited 19 asymptomatic HIV-infected patients, 9 with and 10 without a history of intravenous drug use (IDU), as well as 10 control subjects. All subjects had to have normal MR imaging to be enrolled. We identified the following peaks on proton MRS: n-acetyl aspartate, creatine, choline, and a conglomerate amino acid peak between 2.1 and 2.6 parts per million that we call the marker peaks. Proton MRS was able to demonstrate a statistically significant difference between HIV-infected subjects and controls. The marker/Cr was the best ratio to separate patients from controls, with controls having a mean ratio of 0.50 +/- 0.51 and patients having a mean ratio of 1.8 +/- 0.85 (p = 0.001). There was no difference between HIV-infected subjects with and without a history of IDU. No significant relationship was found between either neuropsychological test scores or CD4 count and metabolite ratios. In brief, MRS seems more sensitive than magnetic resonance imaging (MRI), being able to detect abnormalities in HIV-infected patients when imaging is normal.
引用
收藏
页码:247 / 253
页数:7
相关论文
共 31 条
  • [1] AIDS DEMENTIA COMPLEX - EVALUATION WITH PROTON MR SPECTROSCOPIC IMAGING
    BARKER, PB
    LEE, RR
    MCARTHUR, JC
    [J]. RADIOLOGY, 1995, 195 (01) : 58 - 64
  • [2] CARNE CA, 1985, LANCET, V2, P1206
  • [3] PROTON SPECTROSCOPY OF THE BRAIN IN HIV-INFECTION - CORRELATION WITH CLINICAL, IMMUNOLOGICAL, AND MR-IMAGING FINDINGS
    CHONG, WK
    SWEENEY, B
    WILKINSON, ID
    PALEY, M
    HALLCRAGGS, MA
    KENDALL, BE
    SHEPARD, JK
    BEECHAM, M
    MILLER, RF
    WELLER, IVD
    NEWMAN, SP
    HARRISON, MJG
    [J]. RADIOLOGY, 1993, 188 (01) : 119 - 124
  • [4] CHONG WK, 1994, AM J NEURORADIOL, V15, P21
  • [5] SERIAL PROTON MAGNETIC-RESONANCE SPECTROSCOPY IN ACUTE MULTIPLE-SCLEROSIS LESIONS
    DAVIE, CA
    HAWKINS, CP
    BARKER, GJ
    BRENNAN, A
    TOFTS, PS
    MILLER, DH
    MCDONALD, WI
    [J]. BRAIN, 1994, 117 : 49 - 58
  • [6] EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS AND MULTIPLE-SCLEROSIS - LESION CHARACTERIZATION WITH MAGNETIZATION TRANSFER IMAGING
    DOUSSET, V
    GROSSMAN, RI
    RAMER, KN
    SCHNALL, MD
    YOUNG, LH
    GONZALEZSCARANO, F
    LAVI, E
    COHEN, JA
    [J]. RADIOLOGY, 1992, 182 (02) : 483 - 491
  • [7] Fisher L.D., 1993, BIOSTATISTICS METHOD
  • [8] EVIDENCE FOR EARLY CENTRAL-NERVOUS-SYSTEM INVOLVEMENT IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME (AIDS) AND OTHER HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) INFECTIONS - STUDIES WITH NEUROPSYCHOLOGICAL TESTING AND MAGNETIC-RESONANCE-IMAGING
    GRANT, I
    ATKINSON, JH
    HESSELINK, JR
    KENNEDY, CJ
    RICHMAN, DD
    SPECTOR, SA
    MCCUTCHAN, JA
    [J]. ANNALS OF INTERNAL MEDICINE, 1987, 107 (06) : 828 - 836
  • [9] GROSSMAN RI, 1992, AM J NEURORADIOL, V13, P1535
  • [10] HIRSCH J, IN PRESS AJNR AM J N