Parallel synthesis and structure-activity relationships of a series of highly potent, selective, and neutral factor Xa inhibitors

被引：7

作者：

Bauer, SM

Goldman, EA

Huang, WR

Su, T

Wang, LY

Woolfrey, J

Wu, YH

Zuckett, JMF

Arfsten, A

Huang, B

Kothule, J

Lin, J

May, B

Sinha, U

Wong, PW

Hutchaleelaha, A

Scarborough, RM

Zhu, BY

机构：

[1] Millennium Pharmaceut Inc, Dept Med Chem, San Francisco, CA 94080 USA

[2] Millennium Pharmaceut Inc, Dept Biol, San Francisco, CA 94080 USA

[3] Millennium Pharmaceut Inc, Cardiovasc Res, San Francisco, CA 94080 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 15期

关键词：

factor Xa; SAR; amino acid; aspartic acid;

D O I：

10.1016/j.bmcl.2004.05.033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Parallel synthesis and iterative optimization led to the discovery of a series of potent and specific factor Xa inhibitors demonstrating excellent in vitro activity with promising pharmacokinetics. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4045 / 4050

页数：6

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