Isolation and structure of prorocentrolide B, a fast-acting toxin from Prorocentrum maculosum

被引：65

作者：

Hu, TM

deFreitas, ASW

Curtis, JM

Oshima, Y

Walter, JA

Wright, JLC

机构：

[1] NATL RES COUNCIL CANADA, INST MARINE BIOSCI, HALIFAX, NS B3H 3Z1, CANADA

[2] TOHOKU UNIV, FAC AGR, AOBA KU, SENDAI, MIYAGI, JAPAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 11期

关键词：

D O I：

10.1021/np960439y

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new toxin, prorocentrolide B (1), has been isolated following bioassay-guided fractionation of a BuOH extract of the tropical dinoflagellate, Prorocentrum maculosum Faust. This compound produces a rapid toxic response in the mouse bioassay, a type of activity not accounted for by other diarrhetic shellfish poisoning toxins produced by P. maculosum. The structure 1 was established by NMR and MS and is similar to prorocentrolide (2), a toxin from a strain of Prorocentrum lima. NMR data and the modeling program ConGen have been used to establish the relative stereochemistry of some individual ether ring systems and the hexahydroisoquinoline ring.

引用

页码：1010 / 1014

页数：5

共 20 条

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