Effect of intraoperative intravenous crystalloid infusion on postoperative nausea and vomiting after gynaecological laparoscopy:: comparison of 30 and 10 ml kg-1

被引:72
作者
Magner, JJ
McCaul, C
Carton, E
Gardiner, J
Buggy, D
机构
[1] Rotunda Hosp, Dept Anaesthesia, Dublin 1, Ireland
[2] Hosp Sick Children, Div Anaesthesia, Toronto, ON M5G 1X8, Canada
[3] Hosp Sick Children, Div Intens Care Med, Toronto, ON M5G 1X8, Canada
[4] Hosp Sick Children, Lung Biol Programme, Toronto, ON M5G 1X8, Canada
[5] Mater Misericordiae Univ Hosp, Dept Anaesthesia & Intens Care Med, Dublin 7, Ireland
关键词
anaesthesia; day case; anaesthetic techniques; i.v; infusion; complications; nausea and vomiting; fluids; postoperative nausea and vomiting; surgery; laparoscopy; vomiting; nausea; anaesthetic factors; incidence;
D O I
10.1093/bja/aeh219
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background. I.V. fluid administration has been shown to reduce postoperative nausea and vomiting (PONV). The optimum dose is unknown. We tested the hypothesis that administration of i.v. crystalloid of 30 ml kg(-1) would reduce the incidence of PONV compared with 10 ml kg(-1) of the same fluid. Methods. A total of 141 ASA I female patients undergoing elective gynaecological laparoscopy were randomized, in double-blind fashion, to receive either 10 ml kg(-1) (n=71; CSL-10 group) or 30 ml kg(-1) (n=70; CSL-30 group) of i.v. compound sodium lactate (CSL). Results. In the first 48 h after anaesthesia, the incidence of vomiting was lower in the CSL-30 group than in the CSL-10 group (8.6% vs 25.7%, P=0.01). Anti-emetic use was less in the CSL-30 group at 0.5 h (2.9% vs 14.3%, P=0.04). The incidence of severe nausea was significantly reduced in the treatment group at awakening (2.9% vs 15.7%, P=0.02), 2 h (0.0% vs 8.6%, P=0.04) and cumulatively (5.7% vs 27.1%, P=0.001). The numbers needed to treat to prevent vomiting, severe nausea and antiemetic use in the first 48 h were 6, 5 and 6, respectively. Conclusion. I.V. administration of CSL 30 ml kg(-1) to healthy women undergoing day-case gynaecological laparoscopy reduced the incidence of vomiting, nausea and anti-emetic use when compared with CSL 10 ml kg(-1).
引用
收藏
页码:381 / 385
页数:5
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