Sesquiterpene lactones and scopoletins from Artemisia scoparia Waldst. & Kit. and their angiotensin I-converting enzyme inhibitory activities

被引：28

作者：

Cho, Jeong-Yong ^{[1
,2
]}

Jeong, Seung-Jae ^{[1
,2
]}

Lee, Hee La ^{[1
,2
]}

Park, Kyung-Hee ^{[1
,2
]}

Hwang, Do Young ^{[1
,2
]}

Park, Sun-Young ^{[1
,2
]}

Lee, Yu Geon ^{[3
,4
]}

Moon, Jae-Hak ^{[3
,4
]}

Ham, Kyung-Sik ^{[1
,2
]}

机构：

[1] Mokpo Natl Univ, Dept Food Biotechnol, Muan 58554, Jeonnam, South Korea

[2] Mokpo Natl Univ, Solar Salt Res Ctr, Muan 58554, Jeonnam, South Korea

[3] Chonnam Natl Univ, Dept Food Sci & Technol, Gwangju 61186, South Korea

[4] Chonnam Natl Univ, Funct Food Res Ctr, Gwangju 61186, South Korea

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2016年 / 25卷 / 06期

关键词：

angiotensin I-converting enzyme inhibitor; Artemisia scoparia; sesquiterpene lactone; scoporanolide; scopoletin; IDENTIFICATION; CONSTITUENTS;

D O I：

10.1007/s10068-016-0261-x

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Ten compounds, including a new guaiane-type sesquiterpene lactone, were isolated from the aerial parts of Artemisia scoparia. The structure of the new compound was determined to be 5-hydroxyguaia-3(4),11(13),10(14)-trien-6 alpha,12-olide, named scoparanolide. Six known sesquiterpene lactones [estafiatone, 3 beta,4 alpha-dihydroxyguaia-11(13),10(14)-trien-6 alpha,12-olide, estafiatin, preeupatundin, 3 beta-hydroxycostunolide, and ludovicin B] and three known coumarin derivatives (scopoletin, scoparone, and isofraxidin) were identified by nuclear magnetic resonance and electrospray ionization mass spectroscopy. Six known sesquiterpene lactones were found for the first time in this plant. The angiotensin I-converting enzyme inhibitory activities of coumarin derivatives and scopoletins were significantly higher compared to those of sesquiterpene lactones and quercetin.

引用

页码：1701 / 1708

页数：8

共 35 条

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