Genetic mapping of the human and mouse phospholipase C genes

被引：18

作者：

Lyu, MS

Park, DJ

Rhee, SG

Kozak, CA

机构：

[1] NIAID,MOLEC MICROBIOL LAB,NIH,BETHESDA,MD 20892

[2] NHLBI,LAB SIGNAL TRANSDUCT,NIH,BETHESDA,MD 20892

来源：

MAMMALIAN GENOME | 1996年 / 7卷 / 07期

关键词：

D O I：

10.1007/s003359900151

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To determine chromosome positions for 10 mouse phospholipase C (PLC) genes, we typed the progeny of two sets of genetic crosses for inheritance of restriction enzyme polymorphisms of each PLC. Four mouse chromosomes, Chr 1, 11, 12, and 19, contained single PLC genes. Four PLC loci, Plcb1, Plcb2, Plcb4, and Plcg1, mapped to three sites on distal mouse Chr 2. Two PLC genes, Plcd1 and Plcg2, mapped to distinct sites on Chr 8. We mapped the human homologs of eight of these genes to six chromosomes by analysis of human x rodent somatic cell hybrids. The map locations of seven of these genes were consistent with previously defined regions of conserved synteny; Plcd1 defines a new region of homology between human Chr 3 and mouse Chr 8.

引用

页码：501 / 504

页数：4

共 46 条

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