Vinylogous Mannich reactions.: Additions of trimethylsilyloxyfuran to fluorinated aldimines

被引：37

作者：

Spanedda, MV ^{[1
]}

Ourévitch, M ^{[1
]}

Crousse, B ^{[1
]}

Bégué, JP ^{[1
]}

Bonnet-Delpon, D ^{[1
]}

机构：

[1] Fac Pharm Chatenay Malabry, F-92296 Chatenay Malabry, France

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 26期

关键词：

vinylogous Mannich reaction; trifluoromethyl aldimines; trifluoromethyl butenolides; trifluoromethyl piperidines;

D O I：

10.1016/j.tetlet.2004.05.003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Trifluoromethyl aldimines reacted with trimethylsilyloxyfuran in presence of Lewis acids to provide butenolides in high yields with total diastereoselectivity (>98%). The configuration of these products is anti. The butyrolactone 4a, substituted with a 2-trifluoromethyl ethyl amine, could be converted into a trans alpha-trifluoromethyl piperidine derivative. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5023 / 5025

页数：3

共 17 条

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