Isolation and X-ray crystal structure of racemic xestospongin D from the Singapore marine sponge Niphates sp

被引：18

作者：

Pettit, GR

Orr, B

Herald, DL

Doubek, DL

Tackett, L

Schmidt, JM

Boyd, MR

Pettit, RK

Hooper, JNA

机构：

[1] ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287

[2] NCI,FREDERICK CANC RES & DEV CTR,LAB DRUG DISCOVERY RES & DEV,DTP,DGT,FREDERICK,MD 21702

[3] WESTERN OREGON STATE COLL,DEPT BIOL,MONMOUTH,OR 97361

[4] QUEENSLAND MUSEUM,SESSILE MARINE INVERTEBRATES,BRISBANE,QLD 4101,AUSTRALIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 12期

关键词：

D O I：

10.1016/0960-894X(96)00225-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(+/-)-Xestospongin D (2) has been isolated from the Singapore marine sponge Niphates sp. The natural product was found to be racemic in contrast to earlier isolations of (+)-xestospongin D from Xestospongia and Haliclona species. The (+/-)-xestospongin D was found to inhibit growth of certain human cancer cell lines comprising the NCI panel (e.g., leukemia subpanel, mean GI(50) 3.62 +/- 2.02 x 10(-6)M; breast subpanel, mean GIS, 4.53 +/- 1.98 x 10(-6)M) as well as the murine P388 lymphocytic leukemia (ED(50) 1.7 mu g/mL) and the bacterium Micrococcus luteus. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1313 / 1318

页数：6

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