Schistosoma haematobium and Schistosomiasis mansoni: Production of an estradiol-related compound detected by elisa

被引：29

作者：

Botelho, M. C. ^{[1
,2
]}

Crespo, M. ^{[3
]}

Almeida, A. ^{[1
]}

Vieira, P. ^{[1
]}

Delgado, M. L. ^{[1
]}

Araujo, L. ^{[3
]}

Machado, J. C. ^{[2
,4
]}

Correia da Costa, J. M. ^{[1
]}

机构：

[1] Natl Inst Hlth, CIBP, P-4000055 Oporto, Portugal

[2] Univ Porto, Inst Pathol & Mol Immunol, IPATIMUP, Oporto, Portugal

[3] Portuguese Inst Oncol, Endocrinol Lab, Oporto, Portugal

[4] Univ Porto, Fac Med, P-4100 Oporto, Portugal

来源：

EXPERIMENTAL PARASITOLOGY | 2009年 / 122卷 / 03期

关键词：

Schistosomes; Estradiol; ELISA; ENDOTHELIAL-CELLS; HORMONES; 17-BETA-ESTRADIOL; RECEPTORS;

D O I：

10.1016/j.exppara.2009.04.001

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Estradiol is a steroid hormone secreted principally by the ovarian follicles in vertebrate animals. We have identified the production of an estradiol-related molecule in the trematodes Schistosoma haematobium and Schistosomiasis mansoni. We show in this work that this molecule related to estradiol is present in schistosome worm extracts. The detection method ELISA specific for estradiol, revealed the expression of this estradiol-related molecule in schistosome worm extracts, but not in Fasciola hepatica worm extracts. Our results demonstrate for the first time the production of an estradiol-related compound by a human parasite of the genus Schistosoma. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：250 / 253

页数：4

共 11 条

[1] RESEARCH OF RECEPTORS FOR THE 17-BETA-ESTRADIOL IN SCHISTOSOMA-MANSONI TRYING TO EXPLAIN THE PROTECTING EFFECTS OF THIS HORMONE DURING THE EXPERIMENTAL SCHISTOSOMA-MANSONI PARASITOSIS IN MOUSE - PRELIMINARY-STUDY [J].

BARRABES, A ;

GOMAMOUANDA, J ;

REYNOUARD, F ;

COMBESCOT, C .

ANNALES DE PARASITOLOGIE HUMAINE ET COMPAREE, 1986, 61 (06) :637-641

[2] ESTRADIOL ENHANCES LEUKOCYTE BINDING TO TUMOR-NECROSIS-FACTOR (TNF)-STIMULATED ENDOTHELIAL-CELLS VIA AN INCREASE IN TNF-INDUCED ADHESION MOLECULES E-SELECTIN, INTERCELLULAR-ADHESION MOLECULE TYPE-1, AND VASCULAR CELL-ADHESION MOLECULE TYPE-1 [J].

CID, MC ;

KLEINMAN, HK ;

GRANT, DS ;

SCHNAPER, HW ;

FAUCI, AS ;

HOFFMAN, GS .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (01) :17-25

[3] Latent schistosomiasis in Portuguese soldiers [J].

Cross, John H. ;

Vieira, Paulo ;

Miranda, Helena P. ;

Cerqueira, Manuel ;

Delgado, Maria de Lurdes ;

Coelho, Helen ;

Antunes, Delfina ;

da Costa, Jose M. Correia .

MILITARY MEDICINE, 2007, 172 (02) :144-146

[4] Hormones and nuclear receptors in schistosome development [J].

de Mendonça, RL ;

Escrivá, H ;

Bouton, D ;

Laudet, V ;

Pierce, RJ .

PARASITOLOGY TODAY, 2000, 16 (06) :233-240

[5] Parasite regulation by host hormones: an old mechanism of host exploitation? [J].

Escobedo, G ;

Roberts, CW ;

Carrero, JC ;

Morales-Montor, J .

TRENDS IN PARASITOLOGY, 2005, 21 (12) :588-593

[6] 17β-estradiol transiently disrupts adherens junctions in endothelial cells [J].

Groten, T ;

Pierce, AA ;

Huen, AC ;

Schnaper, HW .

FASEB JOURNAL, 2005, 19 (07) :1368-+

[7] Soluble egg antigens from Schistosoma mansoni induce angiogenesis-related processes by up-regulating vascular endothelial growth factor in human endothelial cells [J].

Loeffler, DA ;

Lundy, SK ;

Singh, KP ;

Gerard, HC ;

Hudson, AP ;

Boros, DL .

JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (11) :1650-1656

[8] ROLES OF ESTRADIOL AND PROGESTERONE IN ELICITING THE MIDCYCLE LUTEINIZING-HORMONE AND FOLLICLE-STIMULATING-HORMONE SURGES [J].

MARCH, CM ;

GOEBELSMANN, U ;

NAKAMURA, RM ;

MISHELL, DR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1979, 49 (04) :507-513

[9] EXCRETION OF ECDYSTEROIDS BY SCHISTOSOMES AS A MARKER OF PARASITE INFECTION [J].

NIRDE, P ;

DEREGGI, ML ;

TSOUPRAS, G ;

TORPIER, G ;

FRESSANCOURT, P ;

CAPRON, A .

FEBS LETTERS, 1984, 168 (02) :235-240

[10] ECDYSONE AND 20-HYDROXYECDYSONE - NEW HORMONES FOR THE HUMAN PARASITE SCHISTOSOMA-MANSONI [J].

NIRDE, P ;

TORPIER, G ;

DEREGGI, ML ;

CAPRON, A .

FEBS LETTERS, 1983, 151 (02) :223-227

← 1 2 →