A user's guide to the human genome

被引:37
作者
Wolfsberg, TG [1 ]
Wetterstrand, KA [1 ]
Guyer, MS [1 ]
Collins, FS [1 ]
Baxevanis, AD [1 ]
机构
[1] NHGRI, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1038/ng964
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The primary aim of A User's Guide to the Human Genome is to provide the reader with an elementary hands-on guide for browsing and analyzing data produced by the International Human Genome Sequencing Consortium and other systematic sequencing efforts. The majority of this supplement is devoted to a series of worked examples, providing an overview of the types of data available, details on how these data can be browsed, and step-by-step instructions for using many of the most commonly-used tools for sequence-based discovery. The major web portals featured throughout include the National Center for Biotechnology Information Map Viewer, the University of California, Santa Cruz Genome Browser, and the European Bioinformatics Institute's Ensembl system, along with many others that are discussed in the individual examples. it is hoped that readers will become more familiar with these resources, allowing them to apply the strategies used in the examples to advance their own research programs.
引用
收藏
页码:4 / 79
页数:76
相关论文
共 39 条
[1]   Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].
Altschul, SF ;
Madden, TL ;
Schaffer, AA ;
Zhang, JH ;
Zhang, Z ;
Miller, W ;
Lipman, DJ .
NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402
[2]  
[Anonymous], 2001, Bioinformatics: A practical guide to the analysis of genes and proteins
[3]   How to count ... human genes [J].
Aparicio, SAJR .
NATURE GENETICS, 2000, 25 (02) :129-130
[4]   InterPro - an integrated documentation resource for protein families, domains and functional sites [J].
Apweiler, R ;
Attwood, TK ;
Bairoch, A ;
Bateman, A ;
Birney, E ;
Biswas, M ;
Bucher, P ;
Cerutti, L ;
Corpet, F ;
Croning, MDR ;
Durbin, R ;
Falquet, L ;
Fleischmann, W ;
Gouzy, J ;
Hermjakob, H ;
Hulo, N ;
Jonassen, I ;
Kahn, D ;
Kanapin, A ;
Karavidopoulou, Y ;
Lopez, R ;
Marx, B ;
Mulder, NJ ;
Oinn, TM ;
Pagni, M ;
Servant, F ;
Sigrist, CJA ;
Zdobnov, EM .
BIOINFORMATICS, 2000, 16 (12) :1145-1150
[5]   The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000 [J].
Bairoch, A ;
Apweiler, R .
NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :45-48
[6]  
Bateman A, 2004, NUCLEIC ACIDS RES, V32, pD138, DOI [10.1093/nar/gkp985, 10.1093/nar/gkh121, 10.1093/nar/gkr1065]
[7]   Genetic control of biochemical reactions in neurospora [J].
Beadle, GW ;
Tatum, EL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1941, 27 :499-506
[8]   The Mouse Genome Database (MGD): the model organism database for the laboratory mouse [J].
Blake, JA ;
Richardson, JE ;
Bult, CJ ;
Kadin, JA ;
Eppig, JT .
NUCLEIC ACIDS RESEARCH, 2002, 30 (01) :113-115
[9]   Errors in genome annotation [J].
Brenner, SE .
TRENDS IN GENETICS, 1999, 15 (04) :132-133
[10]   Finding the genes in genomic DNA [J].
Burge, CB ;
Karlin, S .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1998, 8 (03) :346-354