Solubility and dissolution kinetics of calcium oxalate renal calculi in solutions, containing DL-lysine: in vitro experiments

被引：16

作者：

Atanassova, S

Neykov, K

Gutzow, I ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Inst Chem Phys, BG-1040 Sofia, Bulgaria

[2] Med Univ, Chair Urol, Sofia 1431, Bulgaria

来源：

JOURNAL OF CRYSTAL GROWTH | 2000年 / 212卷 / 1-2期

关键词：

calcium oxalate calculi; lysine; dissolution of crystalline; urine supersaturation;

D O I：

10.1016/S0022-0248(99)00883-0

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

An analysis of dissolution of slightly soluble salts in physiological solutions in the presence of complexing ions was carried out, simulating conditions typical in human urine. It was found that DL-lysine, a normal physiological constituent of urine, acts at increased concentrations as a dissolving agent with respect to calcium oxalate (CaOX) calculi. The kinetics of dissolution of crystalline CaOX calculi in physiological solutions containing DL-lysine at different concentrations were studied, using the change in the Archimedean weight of samples immersed in the solution. The possible effect of lysine as a natural regulator of CaOX supersaturation and crystallization in human urine is also discussed. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：233 / 238

页数：6

共 20 条

[1]

ATANASSOVA S, 1995, J CRYST GROWTH, V160, P148

[2] CRYSTALLIZATION PROCESSES USING REVERSE-OSMOSIS [J].