Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology

被引：726

作者：

Damrauer, Jeffrey S. ^{[1
,6
]}

Hoadley, Katherine A. ^{[1
,6
]}

Chism, David D. ^{[2
,6
]}

Fan, Cheng ^{[1
,6
]}

Tiganelli, Christopher J. ^{[3
]}

Wobker, Sara E. ^{[4
]}

Yeh, Jen Jen ^{[3
,5
,6
]}

Milowsky, Matthew I. ^{[2
,6
]}

Iyer, Gopa ^{[7
]}

Parker, Joel S. ^{[1
,6
]}

Kim, William Y. ^{[1
,2
,6
]}

机构：

[1] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Med, Div Hematol Oncol, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Surg, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA

[5] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA

[6] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[7] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2014年 / 111卷 / 08期

基金：

美国国家卫生研究院;

关键词：

TRANSITIONAL-CELL CARCINOMA; GENE-EXPRESSION; MOLECULAR CHARACTERIZATION; BASAL; IDENTIFICATION; MUTATIONS; SURVIVAL;

D O I：

10.1073/pnas.1318376111

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

We sought to define whether there are intrinsic molecular subtypes of high-grade bladder cancer. Consensus clustering performed on gene expression data from a meta-dataset of high-grade, muscle-invasive bladder tumors identified two intrinsic, molecular subsets of high-grade bladder cancer, termed "luminal" and "basal-like," which have characteristics of different stages of urothelial differentiation, reflect the luminal and basal-like molecular subtypes of breast cancer, and have clinically meaningful differences in outcome. A gene set predictor, bladder cancer analysis of subtypes by gene expression (BASE47) was defined by prediction analysis of microarrays (PAM) and accurately classifies the subtypes. Our data demonstrate that there are at least two molecularly and clinically distinct subtypes of high-grade bladder cancer and validate the BASE47 as a subtype predictor. Future studies exploring the predictive value of the BASE47 subtypes for standard of care bladder cancer therapies, as well as novel subtype-specific therapies, will be of interest.

引用

页码：3110 / 3115

页数：6

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