Amnestic MCI or prodromal Alzheimer's disease?

被引:379
作者
Dubois, B
Albert, ML
机构
[1] Hop La Pitie Salpetriere, Federat Neurol, F-75651 Paris 13, France
[2] Hop La Pitie Salpetriere, INSERM, E007, F-75651 Paris 13, France
[3] Boston Univ, Sch Med, Dept Neurol, Harold Goodglass Aphasia Res Ctr,VA Boston Health, Boston, MA 02118 USA
关键词
D O I
10.1016/S1474-4422(04)00710-0
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The concept of mild cognitive impairment (MCI) draws attention to cognitive changes not severe enough to warrant the diagnosis of dementia. As used today, it covers many pathological disorders and characterises a diverse population of patients who attend memory clinics. Our concern is the underlying heterogeneity. We suggest that it will soon be possible (if it is not already) to identify the underlying pathological disorders before the affected patients meet the criteria of dementia, thanks to specific neuropsychological assessments, neuroimaging, and biomarkers. In particular, patients with Alzheimer's disease (AD), the most important subgroup of patients with MCI, can already be identified before appearance of the fully developed clinical dementia syndrome. Accordingly, this paper proposes diagnostic criteria for "prodromal AD".
引用
收藏
页码:246 / 248
页数:3
相关论文
共 34 条
[1]   Cerebrospinal fluid tau and Aβ42 as predictors of development of Alzheimer's disease in patients with mild cognitive impairment [J].
Andreasen, N ;
Minthon, L ;
Vanmechelen, E ;
Vanderstichele, H ;
Davidsson, P ;
Winblad, B ;
Blennow, K .
NEUROSCIENCE LETTERS, 1999, 273 (01) :5-8
[2]   The detection of mild cognitive impairment in the general practice setting [J].
Artero, S ;
Ritchie, K .
AGING & MENTAL HEALTH, 2003, 7 (04) :251-258
[3]   Age-Associated Memory Impairment: Proposed Diagnostic Criteria and Measures of Clinical Change - Report of a National Institute of Mental Health Work Group [J].
Crook, Thomas ;
Bartus, Raymond T. ;
Ferris, Steven H. ;
Whitehouse, Peter ;
Cohen, Gene D. ;
Gershon, Samuel .
DEVELOPMENTAL NEUROPSYCHOLOGY, 1986, 2 (04) :261-276
[4]   The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease [J].
Delacourte, A ;
David, JP ;
Sergeant, N ;
Buée, L ;
Wattez, A ;
Vermersch, P ;
Ghozali, F ;
Fallet-Bianco, C ;
Pasquier, F ;
Lebert, F ;
Petit, H ;
Di Menza, C .
NEUROLOGY, 1999, 52 (06) :1158-1165
[5]  
Dubois Bruno, 2000, Current Opinion in Neurology, V13, P367, DOI 10.1097/00019052-200008000-00001
[6]  
ENGLER H, 2002, 8 INT C ALZH DIS REL
[7]   MILD COGNITIVE IMPAIRMENT IN THE ELDERLY - PREDICTORS OF DEMENTIA [J].
FLICKER, C ;
FERRIS, SH ;
REISBERG, B .
NEUROLOGY, 1991, 41 (07) :1006-1009
[8]   Influence of age and executive functioning on verbal memory of inpatients with depression [J].
Fossati, P ;
Coyette, F ;
Ergis, AM ;
Allilaire, JF .
JOURNAL OF AFFECTIVE DISORDERS, 2002, 68 (2-3) :261-271
[9]  
GROBER E, 2000, NEUROLOGY, V54, P827, DOI DOI 10.1212/WNL.54.4.827
[10]   Improved discrimination of AD patients using β-amyloid(1-42) and tau levels in CSF [J].
Hulstaert, F ;
Blennow, K ;
Ivanoiu, A ;
Schoonderwaldt, HC ;
Riemenschneider, M ;
De Deyn, PP ;
Bancher, C ;
Cras, P ;
Wiltfang, J ;
Mehta, PD ;
Iqbal, K ;
Pottel, H ;
Vanmechelen, E ;
Vanderstichele, H .
NEUROLOGY, 1999, 52 (08) :1555-1562