Achalasia: Outcome of patients treated with intrasphincteric injection of botulinum toxin

被引:109
作者
Cuilliere, C
Ducrotte, P
Zerbib, F
Metman, EH
deLooze, D
Guillemot, F
Hudziak, H
Lamouliatte, H
Grimaud, JC
Ropert, A
Dapoigny, M
Bost, R
Lemann, M
Bigard, MA
Denis, P
Auget, JL
Galmiche, JP
desVarannes, SB
机构
[1] UNIV HOSP CTR,NANTES,FRANCE
[2] UNIV HOSP CTR,ROUEN,FRANCE
[3] UNIV HOSP CTR,BORDEAUX,FRANCE
[4] UNIV HOSP CTR,TOURS,FRANCE
[5] UNIV HOSP CTR,LILLE,FRANCE
[6] UNIV HOSP CTR,NANCY,FRANCE
[7] UNIV HOSP CTR,MARSEILLE,FRANCE
[8] UNIV HOSP CTR,RENNES,FRANCE
[9] UNIV HOSP CTR,CLERMONT FERRAN,FRANCE
[10] UNIV HOSP CTR,GRENOBLE,FRANCE
[11] UNIV HOSP CTR,PARIS,FRANCE
[12] UNIV HOSP CTR,GHENT,BELGIUM
关键词
achalasia; botulinum toxin; oesophageal motor disorders;
D O I
10.1136/gut.41.1.87
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background - To evaluate the safety and clinical efficacy of botulinum toxin (BT) in patients with achalasia followed up for six months. Methods - Fifty five symptomatic patients with manometrically proven achalasia were included in a multicentre prospective trial. Before and two weeks and two months after intrasphincteric injection of BT, symptoms of dysphagia, regurgitation, and chest pain were scored on a 0-3 scale, and lower oesophageal sphincter pressure (LOSP) was assessed. The symptom score was determined again at six months, clinical improvement being defined by less than or equal to 3, relapse by >3, and failure as a relapse after two injections or loss to follow up. Results - Except for transient chest or epigastric pain (22%), no side effects were observed. There was a significant decrease in LOSP after treatment. Symptom scores were significantly improved at two weeks (2.0 (SD 1.6)), two months (1.7 (1.8)), and six months (1.9 (2.0)) compared with pretreatment values (5.1 (1.8), p<0.001). At six months, 33 patients had clinical improvement (27 after one injection), 17 were considered failures, and five had just relapsed. Although there was a trend for age (older patients being more responsive), age, sex, prior duration of symptoms, initial symptom score, weight loss, LOSP, magnitude of oesophageal contractions, vigorous or non-vigorous achalasia, previous dilatations, and radiological features were not predictive of results. Conclusions - This multicentre series confirms that intrasphincteric injection of BT is a safe procedure, resulting in clinical improvement in 60% of patients with achalasia at six months. The therapeutic role of BT in achalasia needs further evaluation with regard to other alternatives.
引用
收藏
页码:87 / 92
页数:6
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