Synthesis, characterization of novel coupling products and 4-arylhydrazono-2-pyrazoline-5-ones as potential antimycobacterial agents

被引：74

作者：

Küçükgüzel, SG ^{[1
]}

Rollas, S ^{[1
]}

机构：

[1] Marmara univ, Fac Pharm, Dept Pharmaceut Chem, TR-81010 Istanbul, Turkey

来源：

FARMACO | 2002年 / 57卷 / 07期

关键词：

coupling products; 4-arylhydrazono-2-pyrazoline-5-one; 1,2,4-triazole; hydrazide-hydrazones;

D O I：

10.1016/S0014-827X(02)01253-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Novel coupling products 7a-d and 4-arylhydrazono-2 pyrazoline-5-ones 8a-e were synthesized and evaluated for antimycobacterial activity against Mycobacterium tuberculosis H37Rv and Mycobacterium avium. Compound 7b was found to be the most potent derivatives of the 7a-d series by an MIC value of 6.25 mug/ml. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.

引用

页码：583 / 587

页数：5

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