Anatomical and functional imaging of metastatic pheochromocytoma

被引:34
作者
Ilias, A [1 ]
Pacak, K [1 ]
机构
[1] NICHD, Unit Clin Neuroendocrinol, PREB, NIH, Bethesda, MD 20892 USA
来源
STRESS: CURRENT NEUROENDOCRINE AND GENETIC APPROACHES | 2004年 / 1018卷
关键词
pheochromocytoma; computed tomography; magnetic resonance imaging; radionuclide imaging; octreotide; fluorine radioisotopes; positron emission tomography;
D O I
10.1196/annals.1296.061
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Although in the majority of patients with pheochromocytoma the tumor is localized in the adrenal, up to 26% of patients have malignant/metastatic disease. Metastatic disease should be ruled out before initial surgery is attempted. Anatomical imaging modalities (computed tomography or magnetic resonance imaging) should be done first over the adrenals, and if negative over the abdomen and if no tumor is found, then the chest and neck should be covered. Regardless of the anatomical imaging results functional imaging with [123-I]- or [131-I]-metaiodobenzylguanidine (MIBG) scintigraphy should be done to corroborate the diagnosis. Negative MIBG scans should be followed by positron emission tomography (PET) studies with specific ligands like [18-F]-dopamine. Persistently negative evaluations should be followed by PET studies with non-specific ligands such as [18-F]-deoxyglucose or somatostatin receptor scintigraphy.
引用
收藏
页码:495 / 504
页数:10
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