Current concepts in adult stem cell therapy for stroke

被引：37

作者：

Ding, Dah-Ching

Shyu, Woei-Chemg

Lin, Shinn-Zong

Li, Hung ^{[1
]}

机构：

[1] Acad Sinica, Inst Mol Biol, Taipei 115, Taiwan

[2] Tzu Chi Univ, Buddhist Tzu Chi Gen Hosp, Neuromed Sci Ctr, Hualien, Taiwan

[3] Tzu Chi Univ, Grad Inst Med Sci, Sch Med, Hualien, Taiwan

来源：

CURRENT MEDICINAL CHEMISTRY | 2006年 / 13卷 / 29期

关键词：

adult stem cell; stroke; neurogenesis; differentiation;

D O I：

10.2174/092986706779026237

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Acute ischemic stroke causes a disturbance of neuronal circuitry and disruption of the blood-brain-barrier that can lead to functional disabilities. At present, thrombolytic therapy inducing recanalization of the occluded vessels in the cerebral infarcted area is a commonly used therapeutic strategy. However, only a minority. of patients have timely access to this kind of therapy. Therefore, finding other techniques to effectively treat stroke patients is an important research goal. Stem cell therapies, such as adult stem cell transplantation, are promising strategies for the treatment of stroke. Preclinical experimental studies have included the application of human stem cells from various sources including the brain, bone marrow, umbilical cord, and adipose tissue. This review provides an update on current preclinical cell-therapies for stroke, focusing on stem cells derived from adult sources.

引用

页码：3565 / 3574

页数：10

共 128 条

[1]

STRIATAL GRAFTS IN INFARCT STRIATOPALLIDUM INCREASE GABA RELEASE, REORGANIZE GABA, RECEPTOR AND IMPROVE WATER-MAZE LEARNING IN THE RAT [J].