DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections

被引:62
作者
French, Anthony R. [1 ]
Sjolin, Hanna
Kim, Sungjin
Koka, Rima
Yang, Liping
Young, Deborah A.
Cerboni, Cristina
Tomasello, Elena
Ma, Averil
Vivier, Eric
Karre, Klas
Yokoyama, Wayne M.
机构
[1] Washington Univ, Sch Med, Dept Pediat, Div Pediat Rheumatol, St Louis, MO 63110 USA
[2] Karolinska Inst, Ctr Microbiol & Tumor Biol, Stockholm, Sweden
[3] Univ Calif San Francisco, San Francisco, CA 94143 USA
[4] Wyeth Res, Genet Inst, Cambridge, MA 02140 USA
[5] Univ Roma La Sapienza, Dept Expt Med & Pathol, Rome, Italy
[6] Univ Mediterranee, INSERM, CNRS, Ctr Immunol Marseille Luminy, Marseille, France
[7] Washington Univ, Sch Med, Dept Med, Howard Hughes Med Inst, St Louis, MO 63110 USA
[8] Washington Univ, Sch Med, Dept Med, Div Rheumatol, St Louis, MO 63110 USA
关键词
D O I
10.4049/jimmunol.177.8.4981
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
NK cells vigorously proliferate during viral infections. During the course of murine CMV infection, this response becomes dominated by the preferential proliferation of NK cells that express the activation receptor Ly49H: The factors driving such selective NK cell proliferation have not been characterized. In this study, we demonstrate that preferential NK cell proliferation is dependent on DAP12-mediated signaling following the binding of Ly49H to its virally encoded ligand, m157. Ly49H signaling through DAP12 appears to directly augment NK cell sensitivity to low concentrations of proproliferative cytokines such as IL-15. The impact of Ly49H-mediated signaling on NK cell proliferation is masked in the presence of high concentrations of proproliferative cytokines that nonselectively drive all NK cells to proliferate.
引用
收藏
页码:4981 / 4990
页数:10
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