Synbiotics Decrease the Incidence of Septic Complications in Patients with Severe SIRS: A Preliminary Report

被引：66

作者：

Shimizu, Kentaro ^{[1
]}

Ogura, Hiroshi ^{[1
]}

Goto, Miki ^{[1
]}

Asahara, Takashi ^{[2
]}

Nomoto, Koji ^{[2
]}

Morotomi, Masami ^{[2
]}

Matsushima, Asako ^{[1
]}

Tasaki, Osamu ^{[1
]}

Fujita, Kieko ^{[1
]}

Hosotsubo, Hideo ^{[1
]}

Kuwagata, Yasuyuki ^{[1
]}

Tanaka, Hiroshi ^{[1
]}

Shimazu, Takeshi ^{[1
]}

Sugimoto, Hisashi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Traumatol & Acute Crit Med, Suita, Osaka 5650871, Japan

[2] Yakult Cent Inst Microbiol Res, Kunitachi, Tokyo 1860011, Japan

来源：

DIGESTIVE DISEASES AND SCIENCES | 2009年 / 54卷 / 05期

关键词：

Gut; Flora; Short-chain fatty acid; pH; SIRS; Synbiotics; Probiotics; RANDOMIZED CLINICAL-TRIAL; LACTOBACILLUS-CASEI; INTESTINAL FUNCTION; DOUBLE-BLIND; GUT FLORA; INFECTION; THERAPY; MICROFLORA; PROBIOTICS; MICE;

D O I：

10.1007/s10620-008-0460-2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The purpose of this study was to evaluate if synbiotic therapy can correct the deteriorated gut flora and environment in patients with severe systemic inflammatory response syndrome (SIRS). Twenty-nine SIRS patients, who fulfilled a serum C-reactive protein (CRP) level > 10 mg/dl, received synbiotics (Bifidobacterium breve, Lactobacillus casei, and galactooligosaccharides) (S group) and were compared with previous observations in 26 patients without synbiotics (NS group). Analysis of fecal flora confirmed that patients in the S group had significantly greater levels of beneficial Bifidobacterium, Lactobacillus, and total organic acids (particularly short-chain fatty acids) than those in the NS group. The incidence of infectious complications such as enteritis, pneumonia, and bacteremia was significantly lower in the S group than in the NS group. Synbiotics maintain the gut flora and environment and decrease the incidence of septic complications in patients with severe SIRS. Further randomized controlled study is necessary to determine the effects of synbiotics.

引用

页码：1071 / 1078

页数：8

共 41 条

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