Microbiological transformations .32. Use of epoxide hydrolase mediated biohydrolysis as a way to enantiopure epoxides and vicinal diols: Application to substituted styrene oxide derivatives.

被引：92

作者：

PedragosaMoreau, S ^{[1
]}

Archelas, A ^{[1
]}

Furstoss, R ^{[1
]}

机构：

[1] FAC SCI LUMINY,GRP CHIM ORGAN & BIOORGAN,URA CNRS 1320,F-13288 MARSEILLE 9,FRANCE

来源：

TETRAHEDRON | 1996年 / 52卷 / 13期

关键词：

D O I：

10.1016/0040-4020(96)00135-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The biohydrolyses of various substituted styrene oxide derivatives using the fungi Aspergillus niger or Beauveria sulfurescens are described. The results obtained show that this methodology allows the preparation of enantiomerically enriched epoxides and diols via enantioselective and regioselective hydration. The comparative study of the results obtained suggests that these hydrolyses operate following different mechanisms and a model of the corresponding active sites is proposed.

引用

页码：4593 / 4606

页数：14

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