Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19

被引：153

作者：

Zhou, Mei ^{[1
]}

Wang, Xueyan ^{[1
]}

Van Phung ^{[1
]}

Lindhout, Darrin A. ^{[1
]}

Mondal, Kalyani ^{[1
]}

Hsu, Jer-Yuan ^{[1
]}

Yang, Hong ^{[1
]}

Humphrey, Mark ^{[1
]}

Ding, Xunshan ^{[1
]}

Arora, Taruna ^{[1
]}

Learned, R. Marc ^{[1
]}

DePaoli, Alex M. ^{[1
]}

Tian, Hui ^{[1
]}

Ling, Lei ^{[1
]}

机构：

[1] NGM Biopharmaceut Inc, San Francisco, CA 94080 USA

来源：

CANCER RESEARCH | 2014年 / 74卷 / 12期

关键词：

FIBROBLAST-GROWTH-FACTOR; HEPATOCELLULAR-CARCINOMA; LEPTIN RECEPTOR; GENE-EXPRESSION; TRANSGENIC MICE; TUMOR-GROWTH; KAPPA-B; LIVER; STAT3; CANCER;

D O I：

10.1158/0008-5472.CAN-14-0208

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Hepatocellular carcinoma (HCC), one of the leading causes of cancer-related death, develops from premalignant lesions in chronically damaged livers. Although it is well established that FGF19 acts through the receptor complex FGFR4-beta-Klotho (KLB) to regulate bile acid metabolism, FGF19 is also implicated in the development of HCC. In humans, FGF19 is amplified in HCC and its expression is induced in the liver under cholestatic and cirrhotic conditions. In mice, ectopic overexpression of FGF19 drives HCC development in a process that requires FGFR4. In this study, we describe an engineered FGF19 (M70) that fully retains bile acid regulatory activity but does not promote HCC formation, demonstrating that regulating bile acid metabolism is distinct and separable from tumor-promoting activity. Mechanistically, we show that FGF19 stimulates tumor progression by activating the STAT3 pathway, an activity eliminated by M70. Furthermore, M70 inhibits FGF19-dependent tumor growth in a rodent model. Our results suggest that selectively targeting the FGF19-FGFR4 pathway may offer a tractable approach to improve the treatment of chronic liver disease and cancer. (C) 2014 AACR.

引用

页码：3306 / 3316

页数：11

共 45 条

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