Growth hormone-releasing hormone (GHRH) polymorphisms associated with carcass traits of meat in Korean cattle

被引：42

作者：

Cheong, Hyun Sub

Yoon, Du-Hak

Kim, Lyoung Hyo

Park, Byung Lae

Choi, Yoo Hyun

Chung, Eui Ryong

Cho, Yong Min

Park, Eng Woo

Cheong, Il-Cheong

Oh, Sung-Jong

Yi, Sung-Gon

Park, Taesung

Shin, Hyoung Doo ^{[1
]}

机构：

[1] SNP Genet Inc, Dept Genet Epidemiol, Seoul 153803, South Korea

[2] Sangi Univ, Dept Biotechnol, Wonju 220702, Kangwon Do, South Korea

[3] Seoul Natl Univ, Dept Stat, Seoul 151747, South Korea

来源：

BMC GENETICS | 2006年 / 7卷 / 1期

关键词：

D O I：

10.1186/1471-2156-7-35

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: Cold carcass weight (CW) and longissimus muscle area (EMA) are the major quantitative traits in beef cattle. In this study, we found several polymorphisms of growth hormone-releasing hormone (GHRH) gene and examined the association of polymorphisms with carcass traits (CW and EMA) in Korean native cattle (Hanwoo). Results: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 12 single nucleotide polymorphisms within the 9 kb full gene region, including the 1.5 kb promoter region. Among them, six polymorphic sites were selected for genotyping in our beef cattle (n = 428) and five marker haplotypes (frequency > 0.1) were identified. Statistical analysis revealed that - 4241A > T showed significant associations with CW and EMA. Conclusion: Our findings suggest that polymorphisms in GHRH might be one of the important genetic factors that influence carcass yield in beef cattle. Sequence variation/haplotype information identified in this study would provide valuable information for the production of a commercial line of beef cattle.

引用

页数：6

共 24 条

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