Cancer-associated genodermatoses: a personal history

Cancer-associated genodermatoses are a group of genetic disorders inherited in an autosomal-dominant fashion in which unique cutaneous findings are a reliable marker for the risk of developing internal malignancies. The historical, clinical and dermatopathological aspects of basal cell nevus syndrome, Muir-Torre syndrome, Cowden syndrome, Carney complex and Birt-Hogg-Dube syndrome are reviewed in a personal and informal fashion. The latest advances in the molecular genetics of the disorders are also summarized.