Rising prevalence of allergy to peanut in children: Data from 2 sequential cohorts

被引:414
作者
Grundy, J [1 ]
Matthews, S [1 ]
Bateman, B [1 ]
Dean, T [1 ]
Arshad, SH [1 ]
机构
[1] St Marys Hosp, David Hide Asthma & Allergy Res Ctr, Newport, Wight, England
关键词
peanut; allergy; sensitization; prevalence; oral challenge; cohort;
D O I
10.1067/mai.2002.128802
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Allergy to peanut is common. However, it is not known whether the prevalence of sensitization and clinical allergy to peanut is increasing. Objective: We sought to determine any change in the prevalence of peanut sensitization and reactivity in early childhood in 2 sequential cohorts in the same geographic area 6 years apart. Methods: Of 2878 children born between September 1, 1994, and August 31, 1996, living on the Isle of Wight, 1273 completed questionnaires, and 1246 had skin prick tests at the age of 3 to 4 years. Those with positive skin prick test responses to peanut were subjected to oral peanut challenges, unless there was a history of immediate systemic reaction. These data were compared with information on sensitization and clinical allergy to peanut available from a previous cohort born in 1989 in the same geographic area. Results: There was a 2-fold increase in reported peanut allergy (0.5% [6/1218] to 1.0% [13/1273]), but the difference was nonsignificant (P = .2). Peanut sensitization increased 3-fold, with 41 (3.3%) of 1246 children sensitized in 1994 to 1996 compared with 11 (1.1%) of 981 sensitized 6 years ago (P = .001). Of 41 sensitized children in the current study, 10 reported a convincing clinical reaction to peanut, and 8 had positive oral challenge results, giving an overall estimate of peanut allergy of 1.5% (18/1246). Conclusions: Sensitization to peanut had increased between 1989 and 1994 to 1996. There was a strong but statistically nonsignificant trend for increase in reported peanut allergy.
引用
收藏
页码:784 / 789
页数:6
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