Conventional radiotherapy versus concurrent chemoradiotherapy versus accelerated radiotherapy in locoregionally advanced carcinoma of head and neck: Results of a prospective randomized trial

被引：52

作者：

Ghosh-Laskar, Sarbani ^{[1
]}

Kalyani, Nikhil ^{[1
]}

Gupta, Tejpal ^{[1
]}

Budrukkar, Ashwini ^{[1
]}

Murthy, Vedang ^{[1
]}

Sengar, Manju ^{[2
]}

Chaukar, Devendra ^{[3
]}

Pai, Prathamesh ^{[3
]}

Chaturvedi, Pankaj ^{[3
]}

D'Cruz, Anil ^{[3
]}

Agarwal, Jaiprakash ^{[1
]}

机构：

[1] Tata Mem Hosp Ctr, Dept Radiat Oncol, Bombay, Maharashtra, India

[2] Tata Mem Hosp Ctr, Dept Med Oncol, Bombay, Maharashtra, India

[3] Tata Mem Hosp Ctr, Dept Head & Neck Surg Oncol, Bombay, Maharashtra, India

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2016年 / 38卷 / 02期

关键词：

head and neck squamous cell carcinoma (HNSCC); radiotherapy (RT); chemoradiotherapy (CRT); accelerated radiotherapy; cisplatin; CONCOMITANT BOOST RADIOTHERAPY; SQUAMOUS-CELL CARCINOMA; LOCALLY ADVANCED HEAD; WEEKLY CISPLATIN; FRACTIONATION; CHEMOTHERAPY; TOXICITY; CANCERS;

D O I：

10.1002/hed.23865

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 [耳鼻咽喉科学];

摘要：

BackgroundThe purpose of this study was to report the results of a phase III, 3-arm, randomized trial comparing conventional radiotherapy (RT) to concurrent chemoradiotherapy (CRT) and accelerated RT in advanced head and neck squamous cell carcinoma (HNSCC). MethodsOne hundred eighty-six of 750 planned patients were randomized to receive one of the following treatment plans: RT (66-70 Gy/2 Gy fraction/5 fractions weekly; CRT of weekly cisplatin (30 mg/m(2)) with the same RT dose; or accelerated RT alone of 66 to 70 Gy/2 Gy fraction/6 fractions weekly were available for analysis. The primary endpoint was locoregional control at 5 years. ResultsThe mean follow-up was 54 months. Among the 3 arms, CRT showed superior locoregional control (49%; p=.049). RT had lower grade 3 mucositis and late toxicity. ConclusionCRT is associated with significantly better locoregional control as compared to RT and accelerated RT with higher but acceptable acute and late toxicities. (c) 2015 Wiley Periodicals, Inc. Head Neck 38: 202-207, 2016

引用

页码：202 / 207

页数：6

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