Cortical demyelination in multiple sclerosis: A substrate for cognitive deficits?

被引：100

作者：

Kutzelnigg, Alexandra ^{[1
]}

Lassmann, Hans ^{[1
]}

机构：

[1] Med Univ Vienna, Ctr Brain Res, A-1090 Vienna, Austria

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2006年 / 245卷 / 1-2期

基金：

奥地利科学基金会;

关键词：

multiple sclerosis; demyelination; cortex; cognitive deficit;

D O I：

10.1016/j.jns.2005.09.021

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent studies highlight cortical demyelinated lesions as a feature of multiple sclerosis (MS) pathology, which has received little attention so far. Here, we describe that cortical plaques are frequent and widespread, in particular in patients with primary or secondary progressive MS. Furthermore, we describe that certain cortical areas, such as the cingulated gyrus, the insular cortex and the temporobasal cortex, are more affected than others. These data indicate that cortical lesions have to be considered as an additional pathological substrate for cognitive dysfunction in MS patients. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：123 / 126

页数：4

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