Utilization of carbon disulphide for the analytical determination of betahistine hydrochloride and captopril in their pharmaceutical preparations

被引：33

作者：

El Walily, AFM ^{[1
]}

Razak, OA ^{[1
]}

Belal, SF ^{[1
]}

Bakry, RS ^{[1
]}

机构：

[1] Univ Alexandria, Fac Pharm, Dept Pharmaceut Analyt Chem, Alexandria 21521, Egypt

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1999年 / 21卷 / 02期

关键词：

atomic absorption spectrometry; betahistine; captopril; chelates; dithiocarbamate; high performance liquid chromatography; spectrophotometry; trithiocarbonate;

D O I：

10.1016/S0731-7085(99)00159-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Spectrophotometric, atomic absorption spectrometric and high performance liquid chromatographic (HPLC) procedures have been developed for the determination of betahistine hydrochloride and captopril. The three procedures are based on the reaction of the drugs with carbon disulphide in alkaline medium with the formation of the dithiocarbamate or the trithiocarbonate derivative of betahistine (BHT) and captopril (CAP), respectively, then subsequent chelation with divalent metals. The absorbance measurement of the formed chelates or of the metal moiety of chelates was used as the basis for the spectrophotometric and atomic absorption spectrometric determinations. The formed complexes have been used as pre-column derivatizing procedure for the HPLC determination of the two drugs. The different experimental conditions were optimized. The calibration graphs were linear over the applicable concentration ranges. The proposed procedures were applied successfully for the determination of the two investigated drugs in their tablets dosage form. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：439 / 449

页数：11

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