Prader-Willi syndrome - Genetic, behavioral, and treatment issues

被引:45
作者
Dykens, EM
Cassidy, SB
机构
[1] CASE WESTERN RESERVE UNIV,SCH MED,DEPT GENET,CLEVELAND,OH 44106
[2] CASE WESTERN RESERVE UNIV,SCH MED,CTR HUMAN GENET,CLEVELAND,OH 44106
[3] UNIV HOSP CLEVELAND,CLEVELAND,OH 44106
关键词
D O I
10.1016/S1056-4993(18)30340-7
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Prader-Willi syndrome is a complex developmental disorder caused in most cases by absence of paternally derived genes on chromosome 15. Although best known for causing hyperphagia and increased risks of obesity, Prader Willi syndrome actually involves a wide range of physical and behavioral problems. This article reviews genetic and physical features of Prader-Willi syndrome as well as the syndrome's significant behavioral and psychiatric vulnerabilities. Treatment recommendations also are made.
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页码:913 / &
页数:16
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