Is obesity a possible modifier of periodontal disease as a chronic inflammatory process? A case-control study

被引:34
作者
Buduneli, N. [1 ]
Biyikoglu, B. [1 ,4 ]
Ilgenli, T. [1 ]
Buduneli, E. [1 ]
Nalbantsoy, A. [2 ]
Sarac, F. [3 ]
Kinane, D. F. [4 ]
机构
[1] Ege Univ, Sch Dent, Dept Periodontol, TR-35100 Izmir, Turkey
[2] Ege Univ, Sch Engn, Dept Bioengn, TR-35100 Izmir, Turkey
[3] Ege Univ, Sch Med, Dept Endocrinol, TR-35100 Izmir, Turkey
[4] Univ Louisville, Sch Dent, Dept Periodont Endodont & Dent Hyg, Ctr Oral Hlth & Syst Dis, Louisville, KY 40292 USA
关键词
adipokines; cytokines; enzyme-linked immunosorbent assay; obesity; periodontal disease; serum; BODY-MASS INDEX; GINGIVAL CREVICULAR FLUID; INSULIN-RESISTANCE; ADIPOSE-TISSUE; TNF-ALPHA; HEALTH; WEIGHT; INFECTOBESITY; ASSOCIATION; ADIPOKINES;
D O I
10.1111/jre.12125
中图分类号
R78 [口腔科学];
学科分类号
100302 [口腔临床医学];
摘要
Background and Objective: This cross-sectional case-control study was conducted to provide a comparative evaluation of clinical periodontal measurements, together with serum levels of certain bioactive peptides and inflammatory cytokines, in relation to obesity. For this purpose, clinical periodontal measurements and the levels of serum leptin, adiponectin, interleukin-6 (IL-6), C-reactive protein and soluble intercellular adhesion molecule-1 of obese female individuals and their nonobese counterparts were compared. Material and Methods: Sixty obese (body mass index (BMI) > 30) and 31 nonobese (BMI < 30) female subjects were recruited for the present study. Before any periodontal intervention, serum samples were obtained and full-mouth clinical periodontal measurements were recorded at six sites per tooth. ELISA was used for the biochemical analysis. Data were tested statistically. Results: Clinical attachment level was significantly higher in the obese group compared with the nonobese control group (p < 0.05). Serum levels of leptin and IL-6 were significantly higher in the obese group (p < 0.05). BMI correlated with the serum levels of inflammatory molecules (p < 0.05), but not with clinical periodontal parameters, in the obese group. Conclusion: In conclusion, obesity does not seem to have a prominent effect on clinical periodontal parameters but it does have many correlations with circulating inflammatory molecules. As suggested in the literature, increased levels of leptin and IL-6 in the obese group might be one explanation for a possible relationship between obesity and periodontal disease. A prospective study is warranted to clarify, in greater detail, the effects of obesity on periodontal health.
引用
收藏
页码:465 / 471
页数:7
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