Plastic and nonplastic pyramidal cells perform unique roles in a network capable of adaptive redundancy reduction

被引:108
作者
Bastian, J [1 ]
Chacron, MJ
Maler, L
机构
[1] Univ Oklahoma, Dept Zool, Norman, OK 73019 USA
[2] Univ Ottawa, Dept Phys, Ottawa, ON K1N 6N5, Canada
[3] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON K1N 6N5, Canada
基金
加拿大健康研究院; 美国国家卫生研究院;
关键词
D O I
10.1016/S0896-6273(04)00071-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Pyramidal cells show marked variation in their morphology, including dendritic structure, which is correlated with physiological diversity; however, it is not known how this variation is related to a cell's role within neural networks. In this report, we describe correlations among electrosensory lateral line lobe (ELL) pyramidal cells' highly variable dendritic morphology and their ability to adaptively cancel redundant inputs via an anti-Hebbian form of synaptic plasticity. A subset of cells, those with the largest apical dendrites, are plastic, but those with the smallest dendrites are not. A model of the network's connectivity predicts that efficient redundancy reduction requires that nonplastic cells provide feedback input to those that are plastic. Anatomical results confirm the model's prediction of optimal network architecture. These results provide a demonstration of different roles for morphological/physiological variants of a single cell type within a neural network performing a well-defined function.
引用
收藏
页码:767 / 779
页数:13
相关论文
共 50 条
[1]   SOME INFORMATIONAL ASPECTS OF VISUAL PERCEPTION [J].
ATTNEAVE, F .
PSYCHOLOGICAL REVIEW, 1954, 61 (03) :183-193
[2]   DENDRITIC MORPHOLOGY OF CA1 PYRAMIDAL NEURONS FROM THE RAT HIPPOCAMPUS .2. SPINE DISTRIBUTIONS [J].
BANNISTER, NJ ;
LARKMAN, AU .
JOURNAL OF COMPARATIVE NEUROLOGY, 1995, 360 (01) :161-171
[3]   Redundancy reduction revisited [J].
Barlow, H .
NETWORK-COMPUTATION IN NEURAL SYSTEMS, 2001, 12 (03) :241-253
[4]  
Barlow H. B., 1961, P331
[5]   THE ROLE OF AMINO-ACID NEUROTRANSMITTERS IN THE DESCENDING CONTROL OF ELECTRORECEPTION [J].
BASTIAN, J .
JOURNAL OF COMPARATIVE PHYSIOLOGY A-SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, 1993, 172 (04) :409-423
[6]  
Bastian J, 1999, J EXP BIOL, V202, P1327
[7]  
BASTIAN J, 1986, J NEUROSCI, V6, P553
[8]  
BASTIAN J, 1995, J COMP PHYSIOL A, V176, P63
[9]  
Bastian J., 1986, P577
[10]   Receptive field organization determines pyramidal cell stimulus-encoding capability and spatial stimulus selectivity [J].
Bastian, J ;
Chacron, MJ ;
Maler, L .
JOURNAL OF NEUROSCIENCE, 2002, 22 (11) :4577-4590