rab GTPases expressed in human melanoma cells

被引：10

作者：

Chen, D ^{[1
]}

Guo, JR ^{[1
]}

Gahl, WA ^{[1
]}

机构：

[1] NICHHD,SECT HUMAN BIOCHEM GENET,HERITABLE DISORDERS BRANCH,NIH,BETHESDA,MD 20892

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1997年 / 1355卷 / 01期

关键词：

rab; ras superfamily; melanocyte; platelet;

D O I：

10.1016/S0167-4889(96)00169-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression of small GTP-binding protein genes of the ras superfamily was examined in pigmented human melanoma cells by a PCR-based strategy. Twenty six different partial cDNA sequences were isolated, including 17 members of the rab subfamily, of which 9 represented novel genes. Some rabs expressed in melanoma cells overlapped with those of platelets; this should prove relevant to the investigation of murine and human disorders characterized by the combination of pigment dilution and a platelet storage pool defect.

引用

页码：1 / 6

页数：6

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