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The genetic control of organ growth:: insights from Drosophila

被引：88
作者：
Weinkove, D
Leevers, SJ
机构：
[1] Netherlands Canc Inst, Dept Mol Biol, NL-1066 CX Amsterdam, Netherlands
[2] Ludwig Inst Canc Res, London W1P 8BT, England
[3] UCL, Dept Biochem & Mol Biol, London W1P 8BT, England
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2000年 / 10卷 / 01期
关键词：
D O I：
10.1016/S0959-437X(99)00042-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The genetic control of growth ensures that animals grow to reproducible sizes and that tumourous growth is rare. This year, the regulation of organ growth has been studied extensively in Drosophila imaginal discs, and a signalling pathway that regulates organ growth and size has been identified. Furthermore, the role of Drosophila homologues to human tumour suppressor genes and oncogenes in imaginal disc growth has been investigated.
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收藏
页码：75 / 80
页数：6
相关论文
共 52 条
  • [1] 3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase
    Alessi, DR
    Deak, M
    Casamayor, A
    Caudwell, FB
    Morrice, N
    Norman, DG
    Gaffney, P
    Reese, CB
    MacDougall, CN
    Harbison, D
    Ashworth, A
    Bownes, M
    [J]. CURRENT BIOLOGY, 1997, 7 (10) : 776 - 789
  • [2] Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
    Böhni, R
    Riesgo-Escovar, J
    Oldham, S
    Brogiolo, W
    Stocker, H
    Andruss, BF
    Beckingham, K
    Hafen, E
    [J]. CELL, 1999, 97 (07) : 865 - 875
  • [3] BRAND AH, 1993, DEVELOPMENT, V118, P401
  • [4] BRYANT PJ, 1993, DEVELOPMENT, P239
  • [5] INTRINSIC AND EXTRINSIC CONTROL OF GROWTH IN DEVELOPING ORGANS
    BRYANT, PJ
    SIMPSON, P
    [J]. QUARTERLY REVIEW OF BIOLOGY, 1984, 59 (04) : 387 - 415
  • [6] Burke R, 1996, DEVELOPMENT, V122, P2261
  • [7] The Drosophila insulin receptor is required for normal growth
    Chen, C
    Jack, J
    Garofalo, RS
    [J]. ENDOCRINOLOGY, 1996, 137 (03) : 846 - 856
  • [8] Coffer PJ, 1998, BIOCHEM J, V335, P1
  • [9] Cohen Stephen M., 1993, P747
  • [10] Size control in animal development
    Conlon, I
    Raff, M
    [J]. CELL, 1999, 96 (02) : 235 - 244
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