Determination of bismuth in pharmaceutical products using liquid-liquid extraction in a flow injection system

被引：38

作者：

Alonso, A ^{[1
]}

Almendral, MJ ^{[1
]}

Báez, MD ^{[1
]}

Porras, MJ ^{[1
]}

Lávin, FL ^{[1
]}

de María, CG ^{[1
]}

机构：

[1] Univ Salamanca, Fac Chem, Dept Quim Analit Nutr & Bromatol, E-37008 Salamanca, Spain

来源：

ANALYTICA CHIMICA ACTA | 2000年 / 408卷 / 1-2期

关键词：

liquid-liquid extraction; flow injection; bismuth; ion-pair; pharmaceuticals;

D O I：

10.1016/S0003-2670(99)00768-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A flow injection procedure for the determination of bismuth in pharmaceutical products is described. The procedure is based on the formation of an ion-pair between tetraphenylarsonium and the tetraiodobismuthate(III) anion. This ion-pair is extracted with chloroform and the absorbance of the organic phase is measured at 363 or 505 nm. The detection Limit (3 x baseline s.d.) is 1.5 x 10(-6) M (35 ng). The proposed procedure has a relative standard deviation of 1.6% (3.0 x 10(-5) M, n = 12), a linear application range between 2.3 x 10(-6) and 1.5 x 10(-4) M and a sampling frequency of 40 h(-1). Under the proposed working conditions, only Pd(II), Pt(IV) and Au(III) interfere. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：129 / 133

页数：5

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