Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome

被引:68
作者
Pikija, Slaven [1 ]
Cvetko, Danijel [2 ]
Hajduk, Martina [1 ]
Trkulja, Vladimir [3 ]
机构
[1] Cty Hosp Varazdin, Dept Neurol, Varazhdin, Croatia
[2] Cty Hosp Varazdin, Dept Radiol, Varazhdin, Croatia
[3] Univ Zagreb, Sch Med, Zagreb 41001, Croatia
关键词
Ischemic stroke; Stroke outcome; Infarct volume; CT brain scan; Platelets; Mean platelet volume; COMPUTED-TOMOGRAPHY; VISIBLE INFARCTION; CLASSIFICATION; TRIGLYCERIDE; DIAGNOSIS; PROGNOSIS; SUBTYPE; DISEASE;
D O I
10.1016/j.clineuro.2009.04.002
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: Mean platelet volume (MPV) determined shortly after the onset of acute ischemic stroke represents the pre-stroke values. Data on its relationship to stroke severity/outcome have been conflicting. We related MPV to infarct volume on CT brain scans and risk of death/dependence 7 days and 3 months post-stroke. Methods: MPV (within 30 h since stroke onset), infarct volume (13-83 h since stroke onset) and clinical outcomes were evaluated in 81 consecutive patients (32 men, age 52-91 years, 10 small artery occlusion, 10 large artery atherosclerosis, 29 cardioembolic, 32 multiple probable/possible etiology). Results: Higher MPV was independently associated with larger In-infarct volume [estimate 0.259, 95% confidence interval (CI) 0.004-0.513, P=0.046], greater risk of death/dependence 7 days post-stroke [relative risk (RR) = 1.077, 95% CI 1.005-1.115, P = 0.036], and greater risk of death/dependence 3 months post-stroke (RR = 1.077,95% CI 1.001-1.158, P=0.048). Considered covariates: stroke etiology, CT scan timing, platelet count and other hematological parameters, demographic variables, history of cerebrovascular, cardiac or cardiovascular diseases, diabetes, serum chemistry, previous antiplatelet and statin use and treatments delivered after the index event. Conclusions: Data support the view about MPV as a determinant of severity/outcome of the acute ischemic stroke. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:568 / 573
页数:6
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