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Effects of flavonoids on rat aortic smooth muscle contractility: Structure-activity relationships

被引：105
作者：
Herrera, MD
Zarzuelo, A
Jimenez, J
Marhuenda, E
Duarte, J
机构：
[1] UNIV GRANADA, SCH PHARM, DEPT PHARMACOL, E-18071 GRANADA, SPAIN
[2] UNIV SEVILLA, SCH PHARM, DEPT PHARMACOL, SEVILLE, SPAIN
来源：
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1996年 / 27卷 / 02期
关键词：
flavonoid; aorta; rat;
D O I：
10.1016/0306-3623(95)02010-1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Flavonoids produced a concentration dependent relaxation of the contractile responses induced by noradrenaline, KCl, or phorbol 12-myristate-13-acetate in rat aortic rings. Only the flavonoid with three contiguous hydroxyls in B rings (myricetin), at low concentrations, potentiates the contractions evoked by these agonists. 2. The relaxant effects of flavanone on the noradrenaline induced contractions were potentiated by isoprenaline and those of morin, chrysin, flavanone, and naringenin by sodium nitroprusside. 3. Several mechanisms are implicated in the vasodilatory effects of flavonoids: inhibition of protein kinase C; inhibition of cyclic nucleotide phosphodiesterases; and/or decreased Ca2+ uptake.
引用
收藏
页码：273 / 277
页数：5
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