Effect of adenosine A2A receptor stimulation on GABA release from the striatum of young and aged rats in vivo

被引：29

作者：

Corsi, C ^{[1
]}

Melani, A ^{[1
]}

Bianchi, L ^{[1
]}

Pepeu, G ^{[1
]}

Pedata, F ^{[1
]}

机构：

[1] Univ Florence, Dept Preclin & Clin Pharmacol, I-50139 Florence, Italy

来源：

NEUROREPORT | 1999年 / 10卷 / 18期

关键词：

adenosine A(2A) receptor; ageing; GABA; microdialysis; striatum;

D O I：

10.1097/00001756-199912160-00038

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE effect of the adenosine A(2A) receptor agonist CGS 21680 on GABA release from the striatum was investigated in vivo in young and old rats by microdialysis experiments. CGS 21680 at 10 mu M significantly increased GABA spontaneous outflow in young but not in old rats. Conversely, CGS 21680 significantly increased potassium-evoked GABA release in old but not in young rats. The stimulating effect of CGS 21680 on spontaneous GABA release may be both secondary to an increased outflow of excitatory amino acids and to the removal, brought about by A(2A) receptor stimulation, of the inhibitory influence exerted by dopamine through D-2 receptors on GABA-enkephalinergic neurones. The stimulating effect of CGS 21680 on potassium-evoked GABA release in old rats may be ascribed to an age-dependent imbalance in favour of adenosine us dopamine, recently described in the striatum of old rats. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：3933 / 3937

页数：5

共 25 条

[1] ADENOSINE A2A-RECEPTORS IN THE NUCLEUS-ACCUMBENS MEDIATE LOCOMOTOR DEPRESSION [J].

BARRACO, RA ;

MARTENS, KA ;

PARIZON, M ;

NORMILE, HJ .

BRAIN RESEARCH BULLETIN, 1993, 31 (3-4) :397-404

[2] Simultaneous determination of basal and evoked output levels of aspartate, glutamate, taurine and 4-aminobutyric acid during microdialysis and from superfused brain slices [J].

Bianchi, L ;

Della Corte, L ;

Tipton, KF .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1999, 723 (1-2) :47-59

[3] Striatal A2A adenosine receptors differentially regulate spontaneous and K+-evoked glutamate release in vivo in young and aged rats [J].

Corsi, C ;

Melani, A ;

Bianchi, L ;

Pepeu, G ;

Pedata, F .

NEUROREPORT, 1999, 10 (04) :687-691

[4] In vivo amino acid release from the striatum of aging rats: Adenosine modulation [J].

Corsi, C ;

Pazzagli, M ;

Bianchi, L ;

DellaCorte, L ;

Pepeu, G ;

Pedata, F .

NEUROBIOLOGY OF AGING, 1997, 18 (02) :243-250

[5] Tissue distribution of adenosine receptor mRNAs in the rat [J].

Dixon, AK ;

Gubitz, AK ;

Sirinathsinghji, DJS ;

Richardson, PJ ;

Freeman, TC .

BRITISH JOURNAL OF PHARMACOLOGY, 1996, 118 (06) :1461-1468

[6] STIMULATION OF ADENOSINE A2 RECEPTORS INDUCES CATALEPSY [J].

FERRE, S ;

RUBIO, A ;

FUXE, K .

NEUROSCIENCE LETTERS, 1991, 130 (02) :162-164

[7] STIMULATION OF HIGH-AFFINITY ADENOSINE-A2 RECEPTORS DECREASES THE AFFINITY OF DOPAMINE D2 RECEPTORS IN RAT STRIATAL MEMBRANES [J].

FERRE, S ;

VONEULER, G ;

JOHANSSON, B ;

FREDHOLM, BB ;

FUXE, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) :7238-7241

[8] ANTAGONISTIC INTERACTION BETWEEN ADENOSINE A(2A) RECEPTORS AND DOPAMINE D-2 RECEPTORS IN THE VENTRAL STRIOPALLIDAL SYSTEM - IMPLICATIONS FOR THE TREATMENT OF SCHIZOPHRENIA [J].

FERRE, S ;

OCONNOR, WT ;

SNAPRUD, P ;

UNGERSTEDT, U ;

FUXE, K .

NEUROSCIENCE, 1994, 63 (03) :765-773

[9] THE NEOSTRIATAL MOSAIC - MULTIPLE LEVELS OF COMPARTMENTAL ORGANIZATION [J].

GERFEN, CR .

TRENDS IN NEUROSCIENCES, 1992, 15 (04) :133-139

[10] DISTRIBUTION OF STRIATONIGRAL AND STRIATOPALLIDAL PEPTIDERGIC NEURONS IN BOTH PATCH AND MATRIX COMPARTMENTS - AN INSITU HYBRIDIZATION HISTOCHEMISTRY AND FLUORESCENT RETROGRADE TRACING STUDY [J].

GERFEN, CR ;

YOUNG, WS .

BRAIN RESEARCH, 1988, 460 (01) :161-167

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