Novel approach to multichannel SPR sensing

被引：3

作者：

Homola, J ^{[1
]}

Lu, HBB ^{[1
]}

Nenninger, GG ^{[1
]}

Yee, SS ^{[1
]}

Campbell, CT ^{[1
]}

机构：

[1] Univ Washington, Dept Elect Engn, Seattle, WA 98195 USA

来源：

CHEMICAL MICROSENSORS AND APPLICATIONS II | 1999年 / 3857卷

关键词：

surface plasmon resonance; optical sensors; biosensors;

D O I：

10.1117/12.370287

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel approach to multichannel SPR sensing based on encoding information from separate sensing channels into a single optical spectrum is presented. A dual channel SPR sensor using this approach is demonstrated. Attention is given to exploitation of the dual-channel SPR sensor for compensation for background interference and non-specific adsorption of the biomolecules to the surface of the SPR biosensor. Experimental results indicate that background refractive index changes were compensated with accuracy better than 8x10(-5) RIU (refractive index unit); the effect of a temperature change of 3.6 K was reduced by a factor of 13 by the dual-channel sensor. SPR biosensor-based detection of monoclonal anti-dinitrophenyl antibody (a-DNP) with compensation for non-specific adsorption is demonstrated.

引用

页码：198 / 206

页数：9

共 15 条

[1] OPTICAL-PROPERTIES OF AU - SAMPLE EFFECTS [J].