Oligonucleotides covalently linked to an acridine at artificial abasic site: Influence of linker length and the base-sequence

被引：27

作者：

Fukui, K ^{[1
]}

Iwane, K ^{[1
]}

Shimidzu, T ^{[1
]}

Tanaka, K ^{[1
]}

机构：

[1] KYOTO UNIV,GRAD SCH ENGN,DIV MOLEC ENGN,SAKYO KU,KYOTO 60601,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 28期

关键词：

D O I：

10.1016/0040-4039(96)00989-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oligonucleotides covalently linked to an 9-amino-6-chloro-3-methoxyacridine via from a trimethylene to pentamethylene linker were prepared using novel L-threoninol backbone phosphoramidites. Although all of the modified oligonucleotides could bind to the complementary oligonucleotides, the behavior of intercalation of the acridine ring was strongly affected by linker length and the base-sequence. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：4983 / 4986

页数：4

共 16 条

[1] NUCLEIC-ACID BINDING-MOLECULES WITH HIGH-AFFINITY AND BASE SEQUENCE SPECIFICITY - INTERCALATING AGENTS COVALENTLY LINKED TO OLIGODEOXYNUCLEOTIDES
ASSELINE, U
DELARUE, M
LANCELOT, G
TOULME, F
THUONG, NT
MONTENAYGARESTIER, T
HELENE, C
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (11): : 3297 - 3301
[2] OLIGODEOXYNUCLEOTIDES COVALENTLY LINKED TO INTERCALATING DYES AS BASE SEQUENCE-SPECIFIC LIGANDS - INFLUENCE OF DYE ATTACHMENT SITE
ASSELINE, U
TOULME, F
THUONG, NT
DELARUE, M
MONTENAYGARESTIER, T
HELENE, C
[J]. EMBO JOURNAL, 1984, 3 (04) : 795 - 800
[3] A BRIEF SURVEY OF METHODS FOR PREPARING PROTEIN CONJUGATES WITH DYES, HAPTENS, AND CROSS-LINKING REAGENTS
BRINKLEY, M
[J]. BIOCONJUGATE CHEMISTRY, 1992, 3 (01) : 2 - 13
[4] DYNAMICS OF ELECTRON-TRANSFER BETWEEN INTERCALATED POLYCYCLIC MOLECULES - EFFECT OF INTERSPERSED BASES
BRUN, AM
HARRIMAN, A
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (10) : 3656 - 3660
[5] FUKUI K, IN PRESS BIOCONJUGAT
[6] LONG-RANGE PHOTOINDUCED ELECTRON-TRANSFER THROUGH A DNA HELIX
MURPHY, CJ
ARKIN, MR
JENKINS, Y
GHATLIA, ND
BOSSMANN, SH
TURRO, NJ
BARTON, JK
[J]. SCIENCE, 1993, 262 (5136) : 1025 - 1029
[7] NATASI M, 1976, J AM CHEM SOC, V98, P3979
[8] OLIGONUCLEOTIDE LABELING METHODS .3. DIRECT LABELING OF OLIGONUCLEOTIDES EMPLOYING A NOVEL, NONNUCLEOSIDIC, 2-AMINOBUTYL-1,3-PROPANEDIOL BACKBONE
NELSON, PS
KENT, M
MUTHINI, S
[J]. NUCLEIC ACIDS RESEARCH, 1992, 20 (23) : 6253 - 6259
[9] QUANTUM YIELD OF ACRIDINES INTERACTING WITH DNA OF DEFINED BASE SEQUENCES - BASIS FOR EXPLANATION OF ACRIDINE BANDS IN CHROMOSOMES
PACHMANN, U
RIGLER, R
[J]. EXPERIMENTAL CELL RESEARCH, 1972, 72 (02) : 602 - &
[10] A NONNUCLEOTIDE-BASED LINKING METHOD FOR THE PREPARATION OF PSORALEN-DERIVATIZED METHYLPHOSPHONATE OLIGONUCLEOTIDES
REYNOLDS, MA
BECK, TA
HOGREFE, RI
MCCAFFREY, A
ARNOLD, LJ
VAGHEFI, MM
[J]. BIOCONJUGATE CHEMISTRY, 1992, 3 (05) : 366 - 374

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