Synthesis and anti-Pneumocystis carinii activity of piperidine-linked aromatic diimidazolines

被引：17

作者：

Huang, TL

Zhang, Q

White, AT

Queener, SF

Bartlett, MS

Smith, JW

Donkor, IO

机构：

[1] INDIANA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL,INDIANAPOLIS,IN 46202

[2] INDIANA UNIV,SCH MED,DEPT PATHOL & LAB MED,INDIANAPOLIS,IN 46202

[3] UNIV TENNESSEE,CTR HLTH SCI,COLL PHARM,MEMPHIS,TN 38163

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 17期

关键词：

D O I：

10.1016/0960-894X(96)00373-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel piperidine-linked aromatic diimidazolines (3-7) have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii drug, Pentamidine. These compounds significantly inhibited the growth of Pneumocystis carinii in culture at 1 mu g/mL. Copyright (C) 1996 Elsevier Science Ltd

引用

收藏

页码：2087 / 2090

页数：4

相关论文

共 11 条

[1] PNEUMOCYSTIS-CARINII IS RESISTANT TO IMIDAZOLE ANTIFUNGAL AGENTS [J].

BARTLETT, MS ;

QUEENER, SF ;

SHAW, MM ;

RICHARDSON, JD ;

SMITH, JW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (08) :1859-1861

[2] Identification of a class of sulfonamides highly active against dihydropteroate synthase from Toxoplasma gondii, Pneumocystis carinii, and Mycobacterium avium [J].

Chio, LC ;

Bolyard, LA ;

Nasr, M ;

Queener, SF .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (03) :727-733

[3] PENTAMIDINE CONGENERS .1. SYNTHESIS OF CIS-BUTAMIDINE AND TRANS-BUTAMIDINE ANALOGS AS ANTI-PNEUMOCYSTIS-CARINII PNEUMONIA AGENTS [J].

DONKOR, IO ;

JONES, SK ;

TIDWELL, RR .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (06) :1137-1140

[4] PENTAMIDINE CONGENERS .2. 2-BUTENE-BRIDGED AROMATIC DIAMIDINES AND DIIMIDAZOLINES AS POTENTIAL ANTIPNEUMOCYSTIS CARINII PNEUMONIA AGENTS [J].

DONKOR, IO ;

TIDWELL, RR ;

JONES, SK .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (26) :4554-4557

[5] SEQUENCE-DEPENDENT DRUG-BINDING TO THE MINOR-GROOVE OF DNA - CRYSTAL-STRUCTURE OF THE DNA DODECAMER D(CGCAAATTTGCG)(2) COMPLEXED WITH PROPAMIDINE [J].

NUNN, CM ;

NEIDLE, S .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (13) :2317-2325

[6] 8-AMINOQUINOLINES EFFECTIVE AGAINST PNEUMOCYSTIS-CARINII IN-VITRO AND IN-VIVO [J].

QUEENER, SF ;

BARTLETT, MS ;

NASR, M ;

SMITH, JW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (10) :2166-2172

[7] NEW DRUG DEVELOPMENTS FOR OPPORTUNISTIC INFECTIONS IN IMMUNOSUPPRESSED PATIENTS - PNEUMOCYSTIS CARNII [J].

QUEENER, SF .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (24) :4739-4759

[8] SYNTHESIS OF D,L-7,10-ETHANO-5-DEAZAAMINOPTERIN AND L-7,10-ETHANO-5-DEAZAFOLIC ACID [J].

TAYLOR, EC ;

SKOTNICKI, JS ;

FLETCHER, SR .

JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (07) :1005-1010

[9] ANALOGS OF 1,5-BIS(4-AMIDINOPHENOXY)PENTANE (PENTAMIDINE) IN THE TREATMENT OF EXPERIMENTAL PNEUMOCYSTIS-CARINII PNEUMONIA [J].

TIDWELL, RR ;

JONES, SK ;

GERATZ, JD ;

OHEMENG, KA ;

CORY, M ;

HALL, JE .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (04) :1252-1257

[10] ACTIVITY OF CATIONICALLY SUBSTITUTED BIS-BENZIMIDAZOLES AGAINST EXPERIMENTAL PNEUMOCYSTIS-CARINII PNEUMONIA [J].

TIDWELL, RR ;

JONES, SK ;

NAIMAN, NA ;

BERGER, LC ;

BRAKE, WB ;

DYKSTRA, CC ;

HALL, JE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (08) :1713-1716