APC I1307K and the E1317Q variants are not present in Chinese colorectal cancer patients

被引：7

作者：

Guo, JY

Lim, R

Soo, R

Leong, A

Lee, SC

机构：

[1] Natl Univ Singapore Hosp, Dept Haematol Oncol, Singapore 119074, Singapore

[2] Natl Univ Singapore Hosp, Dept Surg, Singapore 119074, Singapore

来源：

GENETICS IN MEDICINE | 2004年 / 6卷 / 04期

关键词：

APC I1307K; APC E1317Q; Asian; Chinese; colorectal cancer;

D O I：

10.1097/01.GIM.0000132687.93304.C6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose: The APC l1307K and E1317Q variants predispose to colorectal adenomas and carcinomas in Caucasians, but data are lacking in Asians. Methods and Results: We sequenced the APC gene from codons 1261 to 1409 and found none of 147 Chinese, 20 Malay, and 11 Indian colorectal cancer patients in Singapore to carry the APC l1307K or E1317Q variants. Conclusion: These variants are rare in these Asian populations, and play little role in colorectal cancer causation in Chinese.

引用

页码：237 / 238

页数：2

共 12 条

[1]

Drucker L, 2000, CANCER-AM CANCER SOC, V88, P755, DOI 10.1002/(SICI)1097-0142(20000215)88:4<755::AID-CNCR4>3.0.CO

[2]

2-7

[3] APC I1307K and E1317Q variants are rare or do not occur in Swedish colorectal cancer patients [J].

Evertsson, S ;

Lindblom, A ;

Sun, XF .

EUROPEAN JOURNAL OF CANCER, 2001, 37 (04) :499-502

[4] The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history [J].

Frayling, IM ;

Beck, NE ;

Ilyas, M ;

Dove-Edwin, I ;

Goodman, P ;

Pack, K ;

Bell, JA ;

Williams, CB ;

Hodgson, SV ;

Thomas, HJW ;

Talbot, IC ;

Bodmer, WF ;

Tomlinson, IPM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (18) :10722-10727

[5] Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC [J].

Laken, SJ ;

Petersen, GM ;

Gruber, SB ;

Oddoux, C ;

Ostrer, H ;

Giardiello, FM ;

Hamilton, SR ;

Hampel, H ;

Markowitz, A ;

Klimstra, D ;

Jhanwar, S ;

Winawer, S ;

Offit, K ;

Luce, MC ;

Kinzler, KW ;

Vogelstein, B .

NATURE GENETICS, 1997, 17 (01) :79-83

[6] Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q [J].

Lamlum, H ;

Al Tassan, N ;

Jaeger, E ;

Frayling, L ;

Sieber, O ;

Bin Reza, F ;

Eckert, M ;

Rowan, A ;

Barclay, E ;

Atkin, W ;

Williams, C ;

Gilbert, J ;

Cheadle, J ;

Bell, J ;

Houlston, R ;

Bodmer, W ;

Sampson, J ;

Tomlinson, L .

HUMAN MOLECULAR GENETICS, 2000, 9 (15) :2215-2221

[7]

Miyoshi Yasuo, 1992, Human Molecular Genetics, V1, P229

[8] The I1307K polymorphism of the APC gene in colorectal cancer [J].

Prior, TW ;

Chadwick, RB ;

Papp, AC ;

Arcot, AN ;

Isa, AM ;

Pearl, DK ;

Stemmermann, G ;

Percesepe, A ;

Loukola, A ;

Aaltonen, LA ;

de la Chapelle, A .

GASTROENTEROLOGY, 1999, 116 (01) :58-63

[9] Clinical and screening implications of the I1307K adenomatous polyposis coli gene variant in Israeli Ashkenazi Jews with familial colorectal neoplasia evidence for a founder effect [J].

Rozen, P ;

Naiman, T ;

Strul, H ;

Taussky, P ;

Karminsky, N ;

Shomrat, R ;

Samuel, Z ;

Yaron, Y ;

Orr-Urtreger, A .

CANCER, 2002, 94 (10) :2561-2568

[10] APC I1304K increases risk of transition from polyp to colorectal carcinoma in Ashkenazi jews [J].

Stern, HS ;

Viertelhausen, S ;

Hunter, AGW ;

O'Rourke, K ;

Cappelli, M ;

Perras, H ;

Serfas, K ;

Blumenthall, A ;

Dewar, D ;

Baumann, E ;

Lagarde, AE .

GASTROENTEROLOGY, 2001, 120 (02) :392-400

← 1 2 →