Mulinane-type diterpenoids from Azorella compaeta display antiplasmodial activity

被引：44

作者：

Loyola, LA

Bórquez, J

Morales, G

San-Martín, A

Darias, J

Flores, N

Giménez, A

机构：

[1] Univ Antofagasta, Fac Ciencias Basicas, Dept Quim, Lab Prod Nat, Antofagasta, Chile

[2] Univ Chile, Fac Ciencias, Dept Quim, Santiago, Chile

[3] CSIC, Inst Prod Nat & Agrobiol, San Cristobal la Laguna 38206, Tenerife, Spain

[4] Univ Mayor San Andres, Fac Ciencias Farmaceut & Bioquim, Inst Invest Farmaco Bioquim, La Paz, Bolivia

来源：

PHYTOCHEMISTRY | 2004年 / 65卷 / 13期

关键词：

Azorella compacta; umbelliferae; diterpenoids; Plasmodium berghei;

D O I：

10.1016/j.phytochem.2004.06.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Two mulinane-type diterpenoids were isolated from Azorella compacta; namely 20-hydroxymulin-11,13-dienyl acetate and 13,14-dihydroxymulin-11-en-20-oic acid. The structures were elucidated by analysis of their spectroscopic data. These compounds, as well as three previously isolated diterpenes, were evaluated as potential in vivo growth inhibitors of Plasmodium berghei NK 65 on infected mice at an intraperitoneal dose of 10 mg/kg/day. Sixty percent and forty-two percent growth inhibition were obtained with 17-acetoxymulin-11,13-dien-20-oic acid and 13,14-dihydroxymulin-11-en-20-oic acid, respectively. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1931 / 1935

页数：5

共 13 条

[1]

A search for natural bioactive compounds in Bolivia through a multidisciplinary approach Part IV.: Is a new haem polymerisation inhibition test pertinent for the detection of antimalarial natural products? [J].