Asymmetric catalytic Mannich reactions catalyzed by urea derivatives:: Enantioselective synthesis of β-aryl-β-amino acids

被引：527

作者：

Wenzel, AG ^{[1
]}

Jacobsen, EN ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 44期

关键词：

D O I：

10.1021/ja028353g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly enantioselective addition reactions between silyl ketene acetals and N-Boc aldimines are catalyzed by the thiourea-based catalyst 1c. Extraordinary scope is observed in this methodology with regard to the imine substrate, with aryl and heteroaromatic derivatives generally affording nearly quantitative yields of β-amino ester product in up to 98% enantioselectivity. Copyright © 2002 American Chemical Society.

引用

页码：12964 / 12965

页数：2

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