Epigenetic inheritance of active chromatin after removal of the main transactivator

被引：198

作者：

Cavalli, G

Paro, R

机构：

[1] Univ Heidelberg, Zentrum Mol Biol, D-69120 Heidelberg, Germany

[2] Inst Human Genet, F-34396 Montpellier, France

来源：

SCIENCE | 1999年 / 286卷 / 5441期

关键词：

D O I：

10.1126/science.286.5441.955

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

The Drosophila Polycomb and trithorax group proteins act through chromosomal elements such as Fab-7 to maintain repressed or active gene expression, respectively. A Fab-7 element is switched from a silenced to a mitotically heritable active state by an embryonic pulse of transcription. Here, histone H4 hyperacetylation was found to be associated with Fab-7 after activation, suggesting that H4 hyperacetylation may be a heritable epigenetic tag of the activated element, Activated Fab-7 enables transcription of a gene even after withdrawal of the primary transcription factor. This feature may allow epigenetic maintenance of active states of developmental genes after decay of their early embryonic regulators.

引用

页码：955 / 958

页数：4

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