A new class of retroviral and satellite encoded small RNAs emanates from mammalian centromeres

被引：101

作者：

Carone, Dawn M. ^{[1
]}

Longo, Mark S. ^{[1
]}

Ferreri, Gianni C. ^{[1
]}

Hall, Laura ^{[1
]}

Harris, Melissa ^{[1
]}

Shook, Nicole ^{[1
]}

Bulazel, Kira V. ^{[1
]}

Carone, Benjamin R. ^{[1
]}

Obergfell, Craig ^{[1
]}

O'Neill, Michael J. ^{[1
]}

O'Neill, Rachel J. ^{[1
]}

机构：

[1] Univ Connecticut, Dept Mol & Cell Biol, Ctr Appl Genet & Technol, Storrs, CT 06269 USA

来源：

CHROMOSOMA | 2009年 / 118卷 / 01期

基金：

美国国家科学基金会;

关键词：

EMBRYONIC STEM-CELLS; DNA; TRANSCRIPTION; DICER; RICE; CHROMOSOME; CHROMATIN; HETEROCHROMATIN; INTERFERENCE; LOCALIZATION;

D O I：

10.1007/s00412-008-0181-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transcriptional framework of the eukaryotic centromere core has been described in budding yeast and rice, but for most eukaryotes and all vertebrates it remains largely unknown. The lack of large pericentric repeats in the tammar wallaby has made it possible to map and identify the transcriptional units at the centromere in a mammalian species for the first time. We show that these transcriptional units, comprised of satellites and a retrovirus, are bound by centromere proteins and that they are the source of a novel class of small RNA. The endogenous retrovirus from which these small RNAs are derived is now known to be in the centromere domain of several vertebrate classes. The discovery of this new RNA form brings together several independent lines of evidence that point to a conserved retroviral-encoded processed RNA entity within eukaryotic centromeres.

引用

页码：113 / 125

页数：13

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