The Canarypox Virus Vector ALVAC Induces Distinct Cytokine Responses Compared to the Vaccinia Virus-Based Vectors MVA and NYVAC in Rhesus Monkeys

被引：57

作者：

Teigler, Jeffrey E. ^{[1
,2
,3
]}

Phogat, Sanjay ^{[4
]}

Franchini, Genoveffa ^{[5
]}

Hirsch, Vanessa M. ^{[6
]}

Michael, Nelson L. ^{[7
]}

Barouch, Dan H. ^{[1
,2
,3
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA

[2] MIT, Ragon Inst MGH, Boston, MA USA

[3] Harvard, Boston, MA USA

[4] Sanofi Pasteur Inc, Swiftwater, PA USA

[5] NCI, Bethesda, MD 20892 USA

[6] NIAID, Bethesda, MD 20892 USA

[7] Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD USA

来源：

JOURNAL OF VIROLOGY | 2014年 / 88卷 / 03期

基金：

美国国家卫生研究院;

关键词：

SIMIAN IMMUNODEFICIENCY; INFECTIOUS-DISEASES; HELA-CELLS; VACCINATION; CANDIDATES; SMALLPOX; STRAIN; PROTECTION; EFFICACY; TROPISM;

D O I：

10.1128/JVI.02386-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Despite the growing use of poxvirus vectors as vaccine candidates for multiple pathogens and cancers, their innate stimulatory properties remain poorly characterized. Here we show that the canarypox virus-based vector ALVAC induced distinct systemic proinflammatory and antiviral cytokine and chemokine levels following the vaccination of rhesus monkeys compared to the vaccinia virus-based vectors MVA and NYVAC. These data suggest that there are substantial biological differences among leading poxvirus vaccine vectors that may influence resultant adaptive immune responses following vaccination.

引用

页码：1809 / 1814

页数：6

共 36 条

[1] The complete genomic sequence of the modified vaccinia Ankara strain: Comparison with other orthopoxviruses [J].

Antoine, G ;

Scheiflinger, F ;

Dorner, F ;

Falkner, FG .

VIROLOGY, 1998, 244 (02) :365-396

[2] POTENTIAL USE OF NONREPLICATING VECTORS AS RECOMBINANT VACCINES [J].

BAXBY, D ;

PAOLETTI, E .

VACCINE, 1992, 10 (01) :8-9

[3]

BENNETT S, 1994, J LEUKOCYTE BIOL, V56, P236

[4] Recombinant vaccine-induced protection against the highly pathogenic simian immunodeficiency virus SIVmac251:: Dependence on route of challenge exposure [J].

Benson, J ;

Chougnet, C ;

Robert-Guroff, M ;

Montefiori, D ;

Markham, P ;

Shearer, G ;

Gallo, RC ;

Cranage, M ;

Paoletti, E ;

Limbach, K ;

Venzon, D ;

Tartaglia, J ;

Franchini, G .

JOURNAL OF VIROLOGY, 1998, 72 (05) :4170-4182

[5] Primary Human Leukocyte Subsets Differentially Express Vaccinia Virus Receptors Enriched in Lipid Rafts [J].

Byrd, Daniel ;

Amet, Tohti ;

Hu, Ningjie ;

Lan, Jie ;

Hu, Sishun ;

Yu, Qigui .

JOURNAL OF VIROLOGY, 2013, 87 (16) :9301-9312

[6] Evasion of apoptosis by DNA viruses [J].

Cuff, S ;

Ruby, J .

IMMUNOLOGY AND CELL BIOLOGY, 1996, 74 (06) :527-537

[7] Systems Analysis of MVA-C Induced Immune Response Reveals Its Significance as a Vaccine Candidate against HIV/AIDS of Clade C [J].

Elena Gomez, Carmen ;

Perdiguero, Beatriz ;

Jimenez, Victoria ;

Filali-Mouhim, Abdelali ;

Ghneim, Khader ;

Haddad, Elias K. ;

Quakkerlaar, Esther D. ;

Delaloye, Julie ;

Harari, Alexandre ;

Roger, Thierry ;

Dunhen, Thomas ;

Sekaly, Rafick P. ;

Melief, Cornelis J. M. ;

Calandra, Thierry ;

Sallusto, Federica ;

Lanzavecchia, Antonio ;

Wagner, Ralf ;

Pantaleo, Giuseppe ;

Esteban, Mariano .

PLOS ONE, 2012, 7 (04)

[8] Removal of Vaccinia Virus Genes That Block Interferon Type I and II Pathways Improves Adaptive and Memory Responses of the HIV/AIDS Vaccine Candidate NYVAC-C in Mice [J].

Elena Gomez, Carmen ;

Perdiguero, Beatriz ;

Luis Najera, Jose ;

Sorzano, Carlos Oscar S. ;

Jimenez, Victoria ;

Gonzalez-Sanz, Ruben ;

Esteban, Mariano .

JOURNAL OF VIROLOGY, 2012, 86 (09) :5026-5038

[9] Improving the MVA Vaccine Potential by Deleting the Viral Gene Coding for the IL-18 Binding Protein [J].

Falivene, Juliana ;

Del Medico Zajac, Maria Paula ;

Pascutti, Maria Fernanda ;

Maria Rodriguez, Ana ;

Maeto, Cynthia ;

Perdiguero, Beatriz ;

Gomez, Carmen E. ;

Esteban, Mariano ;

Calamante, Gabriela ;

Magdalena Gherardi, Maria .

PLOS ONE, 2012, 7 (02)

[10] Short- and long-term immunogenicity and protection induced by non-replicating smallpox vaccine candidates in mice and comparison with the traditional 1st generation vaccine [J].

Ferrier-Rembert, Audrey ;

Drillien, Robert ;

Tournier, Jean-Nicolas ;

Garin, Daniel ;

Crance, Jean-Marc .

VACCINE, 2008, 26 (14) :1794-1804

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